Differences in lipidome and metabolome organization of prefrontal cortex among human populations
文献类型：期刊论文
| 作者 | Tkachev, Anna1,5; Stepanova, Vita1,5; Khrameeva, Ekaterina5; Zubkov, Dmitry5; Khaitovich, Philipp2,5; Zhang, Lei2; Giavalisco, Patrick3; Khaitovich, Philipp4; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2019 |
| 卷号 | 9期号:-页码:18348 |
| 关键词 | FGF21 fasting lysosome autophagy lipid TFEB |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-019-53762-6 |
| 文献子类 | Article |
| 英文摘要 | Human populations, despite their overwhelming similarity, contain some distinct phenotypic, genetic, epigenetic, and gene expression features. In this study, we explore population differences at yet another level of molecular phenotype: the abundance of non-polar and polar low molecular weight compounds, lipids and metabolites in the prefrontal cortical region of the brain. We assessed the abundance of 1,670 lipids and 258 metabolites in 146 Han Chinese, 97 Western European, and 60 African American individuals of varying ages, covering most of the lifespan. The statistical analysis and logistic regression models both demonstrated extensive lipid and metabolic divergence of the Han Chinese individuals from the other two populations. This divergence was age-dependent, peaking in young adults, and involved metabolites and lipids clustering in specific metabolic pathways. |
| 学科主题 | Cell Biology |
| WOS关键词 | FATTY-ACID-COMPOSITION ; HUMAN NERVOUS-SYSTEM ; HUMAN BRAIN ; EVOLUTION ; DISEASE ; MACAQUE ; TISSUE ; MOUSE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31797944 |
| WOS记录号 | WOS:000501431700001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/963]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Russian Acad Sci, Inst Informat Transmiss Problems, Bolshoy Karetny Per 19-1, Moscow 127051, Russia; 2.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 3.Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9B, D-50931 Cologne, Germany; 4.Max Planck Inst Evolutionary Anthropol, Deutsch Pl 6, D-04103 Leipzig, Germany, 5.Skolkovo Inst Sci & Technol, Moscow 121205, Russia; |
| 推荐引用方式 GB/T 7714 | Tkachev, Anna,Stepanova, Vita,Khrameeva, Ekaterina,et al. Differences in lipidome and metabolome organization of prefrontal cortex among human populations[J]. SCIENTIFIC REPORTS,2019,9(-):18348. |
| APA | Tkachev, Anna.,Stepanova, Vita.,Khrameeva, Ekaterina.,Zubkov, Dmitry.,Khaitovich, Philipp.,...&,.(2019).Differences in lipidome and metabolome organization of prefrontal cortex among human populations.SCIENTIFIC REPORTS,9(-),18348. |
| MLA | Tkachev, Anna,et al."Differences in lipidome and metabolome organization of prefrontal cortex among human populations".SCIENTIFIC REPORTS 9.-(2019):18348. |
入库方式： OAI收割
来源：上海营养与健康研究所
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