Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection
文献类型：期刊论文
| 作者 | Cao, Mengtao1,3; Wu, Zhengxi1,3; Lou, Qi1,3; Lu, Wenli1,3; Zhang, Jie1,3; Li, Qi1,3; Zhang, Yifan1,3; Yao, Yikun1,3; Zhao, Qun1,3; Li, Ming1,3 |
| 刊名 | CELL DEATH AND DIFFERENTIATION
 |
| 出版日期 | 2019 |
| 卷号 | 26期号:12页码:2622-2636 |
| 关键词 | Furan fatty acids 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid Metabolism Renal failure Type 2 diabetes |
| ISSN号 | 1350-9047 |
| DOI | 10.1038/s41418-019-0323-8 |
| 文献子类 | Article |
| 英文摘要 | Necroptosis is a recently defined type of programmed cell death with the specific signaling cascade of receptor-interacting protein 1 (RIPK1) and RIPK3 complex to activate the executor MLKL. However, the pathophysiological roles of necroptosis are largely unexplored. Here, we report that fungus triggers myeloid cell necroptosis and this type of cell death contributes to host defense against the pathogen infection. Candida albicans as well as its sensor Dectin-1 activation strongly induced necroptosis in myeloid cells through the RIPK1-RIPK3-MLKL cascade. CARDS, a key adaptor in Dectin-1 signaling, was identified to bridge the RIPK1 and RIPK3 complex-mediated necroptosis pathway. RIPK1 and RIPK3 also potentiated Dectin- 1 -induced MLKL-independent inflammatory response. Both the MLKL-dependent and MLKL-independent pathways were required for host defense against C. albicans infection. Thus, our study demonstrates a new type of host defense system against fungal infection. |
| 学科主题 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| WOS关键词 | MIXED LINEAGE KINASE ; CELL-DEATH ; PROGRAMMED NECROSIS ; LECTIN RECEPTORS ; NECROPTOSIS ; CASPASE-8 ; INFLAMMATION ; PHOSPHORYLATION ; APOPTOSIS ; COMPLEX |
| 语种 | 英语 |
| CSCD记录号 | CSCD:30944411 |
| WOS记录号 | WOS:000496914400011 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/967]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, SIBS, Shanghai 200031, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China, 3.Shanghai Jiao Tong Univ, CAS Key Lab Tissue Microenvironm & Tumor, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Nutr & Hlth,Sch Med, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cao, Mengtao,Wu, Zhengxi,Lou, Qi,et al. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection[J]. CELL DEATH AND DIFFERENTIATION,2019,26(12):2622-2636. |
| APA | Cao, Mengtao.,Wu, Zhengxi.,Lou, Qi.,Lu, Wenli.,Zhang, Jie.,...&,.(2019).Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection.CELL DEATH AND DIFFERENTIATION,26(12),2622-2636. |
| MLA | Cao, Mengtao,et al."Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection".CELL DEATH AND DIFFERENTIATION 26.12(2019):2622-2636. |
入库方式： OAI收割
来源：上海营养与健康研究所
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