Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double
文献类型：期刊论文
| 作者 | Zhao, Huan2,3; Zhou, Bin2,3; Zhou, Bin1,4,5; , |
| 刊名 | CURRENT OPINION IN CELL BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 61期号:-页码:101-109 |
| 关键词 | Uyghurs Xinjiang Eurasia population structure genetic admixture SNP |
| ISSN号 | 0955-0674 |
| DOI | 10.1016/j.ceb.2019.07.004 |
| 文献子类 | Review |
| 英文摘要 | Unravelling stem cell fate plasticity is significant for understanding pathophysiology and exploring new therapeutic targets. The Cre-loxP genetic system is commonly used for cell lineage tracing. However, this conventional approach has limitations that have led to controversies in multiple fields. In recent years, there has been growing interest in a dual genetic approach based on Cre-loxP and another orthogonal recombinase. The dual genetic approach permits cell tracking at a significantly higher resolution and enables a more precise method for gene manipulation and cell fate control. Here, we review the recent progress in dual genetic approaches and highlight emerging work to demonstrate how the application of these approaches advances our understanding of stem cell fate plasticity for tissue repair and regeneration. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| WOS关键词 | CARDIAC STEM-CELLS ; CRE KNOCK-INS ; LIVER PROGENITORS ; C-KIT(+) CELLS ; REGENERATION ; LUNG ; HEPATOCYTES ; RECOMBINASE ; HEART ; IDENTIFICATION |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31446248 |
| WOS记录号 | WOS:000501828200015 |
| 出版者 | CURRENT BIOLOGY LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/970]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Me, Nanjing 211100, Jiangsu, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 4.Jinan Univ, Minist Educ, Key Lab Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Huan,Zhou, Bin,Zhou, Bin,et al. Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double[J]. CURRENT OPINION IN CELL BIOLOGY,2019,61(-):101-109. |
| APA | Zhao, Huan,Zhou, Bin,Zhou, Bin,&,.(2019).Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double.CURRENT OPINION IN CELL BIOLOGY,61(-),101-109. |
| MLA | Zhao, Huan,et al."Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double".CURRENT OPINION IN CELL BIOLOGY 61.-(2019):101-109. |
入库方式： OAI收割
来源：上海营养与健康研究所
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