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Ca(2+) Ion and Autophagy

文献类型：期刊论文

作者Hu, Yang-Xi1; Han, Xiao-Shuai2; Jing, Qing2; ,
刊名AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE
出版日期2019
卷号1206期号:-页码:151-166
ISSN号0065-2598
关键词Calcium Ca(2+) Autophagy IP3R AMPK
DOI10.1007/978-981-15-0602-4_7
文献子类Article; Book Chapter
英文摘要Controlled by a strict mechanism, intracellular calcium (Ca(2+)) is closely related to various cellular activities, including the regulation of autophagy. Researchers believed that under normal or stress state, Ca(2+) has a positive or negative regulation effect on autophagy, the mechanisms of which are different. This bidirectional role of Ca(2+), promotive or suppressing in the regulation of autophagy under different conditions remains controversial, so as the potential mechanisms. Several studies reported that Ca(2+) promotes autophagy through plenty of ways, like inositol 1,4,5-trisphosphate receptor (IP3R) and beclin1 pathway, calmodulin-dependent kinase kinase beta (CaMKK beta)-AMPK-mTOR pathway, mitochondrial energy metabolism-related Ca(2+) uptake, lysosome's regulation of Ca(2+) signal, and so on. Others thought Ca(2+) may inhibit autophagy through IP3R and beclin1-Bcl-2 complex and the AMPK-mTOR pathway, either. It seems to be still a long way to thoroughly understand the truth of Ca(2+) and autophagy.
学科主题Oncology ; Cell Biology
WOS关键词CA2+
语种英语
CSCD记录号CSCD:31776984
出版者SPRINGER-VERLAG SINGAPORE PTE LTD
WOS记录号WOS:000514094300007
版本出版稿
源URL[http://202.127.25.144/handle/331004/973]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Changhai Hosp, Dept Cardiol, 168 Changhai Rd, Shanghai 200433, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, 320 Yueyang Rd, Shanghai 200031, Peoples R China,
推荐引用方式
GB/T 7714		 Hu, Yang-Xi,Han, Xiao-Shuai,Jing, Qing,et al. Ca(2+) Ion and Autophagy[J]. AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE,2019,1206(-):151-166.
APA Hu, Yang-Xi,Han, Xiao-Shuai,Jing, Qing,&,.(2019).Ca(2+) Ion and Autophagy.AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE,1206(-),151-166.
MLA Hu, Yang-Xi,et al."Ca(2+) Ion and Autophagy".AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE 1206.-(2019):151-166.

入库方式： OAI收割

来源：上海营养与健康研究所

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