Genetic variants associated with skin aging in the Chinese Han population
文献类型：期刊论文
| 作者 | Gao, Wenshan1,6; Ding, Anan1; Liu, Yu1; Jin, Li1,2,7; Wang, Sijia1,2,7; Tan, Jingze2,7; Huels, Anke3; Vierkoetter, Andrea3; Krutmann, Jean3; Schikowski, Tamara3 |
| 刊名 | JOURNAL OF DERMATOLOGICAL SCIENCE
 |
| 出版日期 | 2017 |
| 卷号 | 86期号:1页码:21-29 |
| 关键词 | Skin aging Chinese Han population Candidate SNPs Candidate genes |
| ISSN号 | 0923-1811 |
| DOI | 10.1016/j.jdermsci.2016.12.017 |
| 文献子类 | Article |
| 英文摘要 | Background: The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations. The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood. Objective: To investigate the genetic risk factors of relevance for skin aging in East Asians, we conducted the first candidate gene study for signs of skin aging in Han Chinese. Methods: We collected skin aging and genotype data in 502 female Han Chinese from the Taizhou cohort. We evaluated skin aging by the validated skin aging score SCINEXA (TM). Confounding factors were assessed through a questionnaire. We obtained the genotype data for 21 candidate SNPs and for a further 509 SNPs from 16 related candidate genes. Associations were tested by linear and logistic regression analyses and adjusted for potential confounders. Results: Our candidate study found a significant association between SNP rs2066853 in exon 10 of the aryl hydrocarbon receptor gene AHR and crow's feet. In addition, we found a significant association between SNP rs10733310 in intron 5 of BNC2 and pigment spots on the arms, and between SNP rs11979919, 3 kb downstream of COL1A2, and laxity of eyelids. Conclusions: Our results identified genetic risk factors for signs of skin aging (pigmentation, wrinkles or laxity) in Han Chinese. We also found that the manifestation of skin aging is further modified by anatomical site. Together with previous work, our results also suggest that different genetic variants could be responsible for distinct skin aging signs characteristic of Caucasians compared to East Asians. (C) 2017 The Authors. Published by Elsevier Ireland Ltd on behalf of Japanese Society for Investigative Dermatology. |
| 学科主题 | Dermatology |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; EHLERS-DANLOS-SYNDROME ; COL1A2 GENE ; POLYMORPHISMS ; WOMEN ; MUTATIONS ; BNC2 |
| 语种 | 英语 |
| WOS记录号 | WOS:000400203300003 |
| 出版者 | ELSEVIER IRELAND LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/974]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Beijing, Peoples R China; 2.Fudan Univ, Key Lab Contemporary Anthropol, Collaborat Innovat Ctr Genet & Dev, Minist Educ,Sch Life Sci, Shanghai 200438, Peoples R China; 3.IUF Leibniz Res Inst Environm Med, Auf&rsquo M Hennekamp 50, D-40225 Dusseldorf, Germany; 4.Fudan Taizhou Inst Hlth Sci, Taizhou 225300, Jiangsu, Peoples R China; 5.Estee Lauder Co Inc, Melville, NY USA, 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 7.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Shanghai 200438, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gao, Wenshan,Ding, Anan,Liu, Yu,et al. Genetic variants associated with skin aging in the Chinese Han population[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2017,86(1):21-29. |
| APA | Gao, Wenshan.,Ding, Anan.,Liu, Yu.,Jin, Li.,Wang, Sijia.,...&,.(2017).Genetic variants associated with skin aging in the Chinese Han population.JOURNAL OF DERMATOLOGICAL SCIENCE,86(1),21-29. |
| MLA | Gao, Wenshan,et al."Genetic variants associated with skin aging in the Chinese Han population".JOURNAL OF DERMATOLOGICAL SCIENCE 86.1(2017):21-29. |
入库方式： OAI收割
来源：上海营养与健康研究所
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