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Genome engineering of stem cell organoids for disease modeling

文献类型：期刊论文

作者Sun, Yingmin1,2; Ding, Qiurong1,2; ,
刊名PROTEIN & CELL
出版日期2017
卷号8期号:5页码:315-327
关键词pluripotent/adult stem cell tissue organoid genome editing precision medicine
ISSN号1674-800X
DOI10.1007/s13238-016-0368-0
文献子类Article
英文摘要Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. With recent development in stem cell field, a variety of tissue organoids can be derived from patient specific pluripotent stem cells and adult stem cells. In combination with the state-of-the-art genome editing tools, organoids can be further engineered to mimic disease-relevant genetic and epigenetic status of a patient. This has therefore enabled a rapid expansion of sophisticated in vitro disease models, offering a unique system for fundamental and biomedical research as well as the development of personalized medicine. Here we summarize some of the latest advances and future perspectives in engineering stem cell organoids for human disease modeling.
学科主题Cell Biology
语种英语
WOS记录号WOS:000400651900001
出版者HIGHER EDUCATION PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/975]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, CAS Key Lab Nutr & Metab, Shanghai 200031, Peoples R China;
2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China,
推荐引用方式
GB/T 7714		 Sun, Yingmin,Ding, Qiurong,,. Genome engineering of stem cell organoids for disease modeling[J]. PROTEIN & CELL,2017,8(5):315-327.
APA Sun, Yingmin,Ding, Qiurong,&,.(2017).Genome engineering of stem cell organoids for disease modeling.PROTEIN & CELL,8(5),315-327.
MLA Sun, Yingmin,et al."Genome engineering of stem cell organoids for disease modeling".PROTEIN & CELL 8.5(2017):315-327.

入库方式： OAI收割

来源：上海营养与健康研究所

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