Effect of light on blinking in patients with idiopathic isolated blepharospasm
文献类型：期刊论文
| 作者 | Wu, Yiwen1,2,3,4,8,9; Cho, Hyun Joo4; Panyakaew, Pattamon4; Savant, Charulata Sankhla4; Dang, Nguyet4; Hallett, Mark4; Panyakaew, Pattamon5; Savant, Charulata Sankhla6; Wu, Tianxia7; , |
| 刊名 | PARKINSONISM & RELATED DISORDERS
 |
| 出版日期 | 2019 |
| 卷号 | 67期号:-页码:66-71 |
| 关键词 | Blepharospasm Dystonia Photophobia Blink rate |
| ISSN号 | 1353-8020 |
| DOI | 10.1016/j.parkreldis.2019.09.010 |
| 文献子类 | Article |
| 英文摘要 | Objective: Melanopsin may be involved in the pathophysiology of photophobia in idiopathic isolated blepharospasm. We assessed the efficacy of blocking wavelengths of melanopsin absorption to reduce blinking in blepharospasm as a possible surrogate for photophobia. Methods: Twenty-one participants (11 blepharospasm and 10 healthy controls) were studied. There were three sessions: (1) a baseline condition to measure the blink rate (BR) without intervention; (2) two conditions where the participants received intermittent light stimuli with high or low intensity without wearing study lenses; (3) four conditions in which the participants received intermittent light stimuli with high intensity while wearing one of four different lenses: tinted lenses with neutral gray or FL-41, or coated lenses that block 480-nm or 590-nm wavelength. The primary outcome measure was the BR. Results: The blepharospasm group blinked more frequently than controls in dim room conditions. Patients reported greater photosensitivity compared to controls based on the questionnaire and exhibited a higher BR with intermittent light stimuli. The BR decreased for both groups when using 480-nm and 590-nm blocking lenses. In the patients, 480-nm and 590-nm blocking lenses reduced the mean BR by 9.6 blink/min and 10.3 blink/min, respectively, while in the control group, the mean BR decreased by 4.4 blink/min and 4.3 blink/min, respectively. Conclusions: Blepharospasm patients had increased BR with light stimuli which decreased with 590-nm and 480-nm blocking lenses. The 480-nm- and 590-nm- coated lenses might have therapeutic potential in treating photophobia although BR does not appear to be an optimal biomarker for photophobia. |
| 学科主题 | Agriculture ; Genetics & Heredity |
| WOS关键词 | RETINAL GANGLION-CELLS ; DYSTONIA |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31621610 |
| WOS记录号 | WOS:000500037800014 |
| 出版者 | ELSEVIER SCI LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/977]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Lab Neurodegenerat Dis, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; 2.Chinese Acad Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 4.NINDS, Human Motor Control Sect, NIH, 10 Ctr Dr MSC 1428,Bldg 10,Room 7D37, Bethesda, MD 20892 USA; 5.Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Dept Med, Bangkok, Thailand; 6.PD Hinduja Natl Hosp, V Savakar Marg, Mumbai, Maharashtra, India; 7.NINDS, Clin Trials Unit, Off Clin Director, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA, 8.Shanghai Jiao Tong Univ, Sch Med, Inst Neurol, RuiJin Hosp, Shanghai, Peoples R China; 9.Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Yiwen,Cho, Hyun Joo,Panyakaew, Pattamon,et al. Effect of light on blinking in patients with idiopathic isolated blepharospasm[J]. PARKINSONISM & RELATED DISORDERS,2019,67(-):66-71. |
| APA | Wu, Yiwen.,Cho, Hyun Joo.,Panyakaew, Pattamon.,Savant, Charulata Sankhla.,Dang, Nguyet.,...&,.(2019).Effect of light on blinking in patients with idiopathic isolated blepharospasm.PARKINSONISM & RELATED DISORDERS,67(-),66-71. |
| MLA | Wu, Yiwen,et al."Effect of light on blinking in patients with idiopathic isolated blepharospasm".PARKINSONISM & RELATED DISORDERS 67.-(2019):66-71. |
入库方式： OAI收割
来源：上海营养与健康研究所
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