Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade
文献类型：期刊论文
| 作者 | Zhang, Qian8,9; Meng, Fansen8,9; Chen, Shasha8,9; Wu, Shiying8,9; Liu, Shengduo8,9; Li, Xinran8,9; Zhou, Ruyuan8,9; Wang, Junxian8,9; Zhao, Bin8,9; Feng, Xin-Hua8,9 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:4页码:362-+ |
| 关键词 | biomass breeding climate change crop yield decision support system |
| ISSN号 | 1465-7392 |
| DOI | 10.1038/ncb3496 |
| 文献子类 | Article |
| 英文摘要 | The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular and tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral defence. The correlation between cellular nutrient/physical status and host antiviral defence is interesting but not well understood. Here we find that YAP/TAZ act as natural inhibitors of TBK1 and are vital for antiviral physiology. Independent of transcriptional regulation and through the transactivation domain, YAP/TAZ associate directly with TBK1 and abolish virus-induced TBK1 activation, by preventing TBK1 Lys63-linked ubiquitylation and the binding of adaptors/substrates. Accordingly, YAP/TAZ deletion/depletion or cellular conditions inactivating YAP/TAZ through Lats1/2 kinases relieve TBK1 suppression and boost antiviral responses, whereas expression of the transcriptionally inactive YAP dampens cytosolic RNA/DNA sensing and weakens the antiviral defence in cells and zebrafish. Thus, we describe a function of YAP/TAZ and the Hippo pathway in innate immunity, by linking cellular nutrient/physical status to antiviral host defence. |
| 学科主题 | Cell Biology |
| WOS关键词 | ORGAN SIZE CONTROL ; GMP-AMP SYNTHASE ; BINDING KINASE 1 ; NF-KAPPA-B ; CELL SELF-RENEWAL ; INNATE IMMUNITY ; PROMOTES APOPTOSIS ; YAP PATHWAY ; IKK-EPSILON ; RIG-I |
| 语种 | 英语 |
| WOS记录号 | WOS:000397917000014 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/978]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA; 2.Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA; 3.Harvard Med Sch, Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA; 4.Chinese Acad Sci, Key Lab Stem Cell Biol, Chinese Acad Sci Ctr Excellence Mol Cell Sci, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 5.Zhejiang Univ, Inst Translat Med, Affiliated Hosp 2, Eye Ctr,Sch Med, Hangzhou 310058, Zhejiang, Peoples R China; 6.Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA; 7.Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA, 8.Zhejiang Univ, Inst Life Sci, Hangzhou 310058, Zhejiang, Peoples R China; 9.Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Qian,Meng, Fansen,Chen, Shasha,et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade[J]. NATURE CELL BIOLOGY,2017,19(4):362-+. |
| APA | Zhang, Qian.,Meng, Fansen.,Chen, Shasha.,Wu, Shiying.,Liu, Shengduo.,...&,.(2017).Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade.NATURE CELL BIOLOGY,19(4),362-+. |
| MLA | Zhang, Qian,et al."Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade".NATURE CELL BIOLOGY 19.4(2017):362-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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