Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-kappa B-NLRP3 Pathway
文献类型：期刊论文
| 作者 | Liu, Jiameng3; Mao, Chaoming3; Dong, Liyang3; Kang, Ping3; Ding, Chao3; Zheng, Tingting3; Wang, Xuefeng3; Xiao, Yichuan1,2; , |
| 刊名 | FRONTIERS IN ENDOCRINOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:778 |
| 关键词 | excessive iodine Hashimoto's thyroiditis pyroptosis reactive oxygen species NLRP3 inflammasome |
| ISSN号 | 1664-2392 |
| DOI | 10.3389/fendo.2019.00778 |
| 文献子类 | Article |
| 英文摘要 | Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disease. In recent years, increasing evidence has proven that the incidence of HT is associated with the excessive iodine intake of the body. In the present study, we measured the status of pyroptosis in thyroid tissues from patients with HT and the effects of excessive iodine on the pyroptosis in thyroid follicular cells (TFCs), in an attempt to illuminate the effects of iodine excess on the development of HT disease. Our results showed that increased pyroptosis occurred in the thyroid tissues of HT patients and that an increase in pyroptosis activity in TFCs was primed by excessive iodine in vitro. This process was mediated by reactive oxygen species (ROS) and activation of the NF-kappa B signaling pathway. In addition, excessive iodine caused NLRP3 inflammasome activation in TFCs, which promoted TFC pyroptosis. Moreover, the release of interleukin-1 beta (IL-1 beta) was closely linked to pyroptosis activation. Taken together, our results suggested that excessive iodine contributed to aberrant activation of pyroptosis in TFCs, which could be a pivotal predisposing factor for HT development. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | GASDERMIN D ; DEATH ; DISEASES ; INTERLEUKIN-1 ; INFLAMMASOME ; PREVALENCE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31824415 |
| WOS记录号 | WOS:000501285900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/980]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China; 3.Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, Zhenjiang, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Jiameng,Mao, Chaoming,Dong, Liyang,et al. Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-kappa B-NLRP3 Pathway[J]. FRONTIERS IN ENDOCRINOLOGY,2019,10(-):778. |
| APA | Liu, Jiameng.,Mao, Chaoming.,Dong, Liyang.,Kang, Ping.,Ding, Chao.,...&,.(2019).Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-kappa B-NLRP3 Pathway.FRONTIERS IN ENDOCRINOLOGY,10(-),778. |
| MLA | Liu, Jiameng,et al."Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-kappa B-NLRP3 Pathway".FRONTIERS IN ENDOCRINOLOGY 10.-(2019):778. |
入库方式： OAI收割
来源：上海营养与健康研究所
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