USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein
文献类型：期刊论文
| 作者 | Chen, Siyuan1; Yun, Fenglin1; Yao, Yikun1; Cao, Mengtao1; Zhang, Yifan1; Wang, Jingjing1; Song, Xinyang1; Qian, Youcun1,2; Yun, Fenglin2; , |
| 刊名 | JOURNAL OF EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2018 |
| 卷号 | 215期号:11页码:2850-2867 |
| ISSN号 | 0022-1007 |
| DOI | 10.1084/jem.20172026 |
| 文献子类 | Article |
| 英文摘要 | Th2 immune response is critical for allergic asthma pathogenesis. Molecular mechanisms for regulating Th2 immunity are still not well understood. Here we report that the ubiquitin-specific protease USP38 is crucial for Th2-mediated allergic asthma. TCR stimulation up-regulated the USP38 level, and USP38 in turn mediated the protein stabilization of JunB, a transcription factor specific for Th2 development. Consequently, USP38 was specifically required for TCR-induced production of Th2 cytokines and Th2 development both in vitro and in vivo, and USP38-deficient mice were resistant to asthma pathogenesis induced by OVA or HDM. Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover. USP38 represents the first identified deubiquitinase specifically for Th2 immunity and the associated asthma. |
| 学科主题 | Immunology ; Research & Experimental Medicine |
| WOS关键词 | HELPER-CELL DIFFERENTIATION ; E3 UBIQUITIN LIGASES ; NF-KAPPA-B ; DEUBIQUITINATING ENZYMES ; T-CELLS ; INFLAMMATORY RESPONSES ; T(H)2 DIFFERENTIATION ; ITCH ; ACTIVATION ; EXPRESSION |
| 语种 | 英语 |
| WOS记录号 | WOS:000449278300014 |
| 出版者 | ROCKEFELLER UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/982]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci,Shanghai Inst Nutr & Hlth, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Key Lab Tissue Microenvironm & Tumor, Shanghai, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Siyuan,Yun, Fenglin,Yao, Yikun,et al. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2018,215(11):2850-2867. |
| APA | Chen, Siyuan.,Yun, Fenglin.,Yao, Yikun.,Cao, Mengtao.,Zhang, Yifan.,...&,.(2018).USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.JOURNAL OF EXPERIMENTAL MEDICINE,215(11),2850-2867. |
| MLA | Chen, Siyuan,et al."USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein".JOURNAL OF EXPERIMENTAL MEDICINE 215.11(2018):2850-2867. |
入库方式： OAI收割
来源：上海营养与健康研究所
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