HIC1 loss promotes prostate cancer metastasis by triggering epithelial - mesenchymal transition
文献类型：期刊论文
| 作者 | Hao, Mingang2; Wang, Yingying2; Sun, Xueqing2; Li, Yue6; Wang, Jinglong6; Zu, Lidong6; Qin, Jun4,7; Ding, Yufeng4,7; Jiang, Min4,7; Chang, Kun5 |
| 刊名 | JOURNAL OF PATHOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 242期号:4页码:409-420 |
| 关键词 | HIC prostate cancer EMT metastasis |
| ISSN号 | 0022-3417 |
| DOI | 10.1002/path.4913 |
| 文献子类 | Article |
| 英文摘要 | Metastatic disease is the leading cause of death due to prostate cancer (PCa). Although the hypermethylated in cancer 1 (HIC1) gene has been observed to be epigenetically modified in PCa, its intrinsic role and mechanism in PCa metastasis still remain uncertain. Here, we show that hypermethylation of the HIC1 promoter markedly reduces its suppressive function in metastatic PCa tissues as compared with primary and adjacent normal prostate tissues, and is associated with poor patient survival. PCas in cancer-prone mice homozygous for a prostate-targeted Hic1 conditional knockout showed stronger metastatic behaviour than those in heterozygous mice, as a result of epithelial-mesenchymal transition (EMT). Moreover, impairment of HIC1 expression in PCa cells induced their migration and metastasis through EMT, by enhancing expression of Slug and CXCR4, both of which are critical to PCa metastasis; the CXCL12-CXCR4 axis promotes EMT by activating the extracellular signal-regulated kinase (ERK) 1/2 pathway. Taken together, our results suggest that evaluation of HIC1-CXCR4-Slug signalling may provide a potential predictor for PCa aggressiveness. Copyright (C) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| 学科主题 | Oncology ; Pathology |
| WOS关键词 | TUMOR-SUPPRESSOR GENE ; DNA HYPERMETHYLATION ; BREAST-CANCER ; D17S5 LOCUS ; TRANSCRIPTIONAL REGULATION ; DRIVES PROGRESSION ; E-CADHERIN ; PTEN LOSS ; EXPRESSION ; GROWTH |
| 语种 | 英语 |
| WOS记录号 | WOS:000406160500004 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/983]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Shanghai Canc Ctr, Canc Inst, Shanghai 200032, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol & Cell Biol, Shanghai, Peoples R China; 3.Acad Sci Czech Republ, Inst Mol Genet, Dept Cell & Dev Biol, Prague, Czech Republic, 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 5.Fudan Univ, Shanghai Canc Ctr, Dept Urol, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Pathol Ctr, Shanghai, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hao, Mingang,Wang, Yingying,Sun, Xueqing,et al. HIC1 loss promotes prostate cancer metastasis by triggering epithelial - mesenchymal transition[J]. JOURNAL OF PATHOLOGY,2017,242(4):409-420. |
| APA | Hao, Mingang.,Wang, Yingying.,Sun, Xueqing.,Li, Yue.,Wang, Jinglong.,...&,.(2017).HIC1 loss promotes prostate cancer metastasis by triggering epithelial - mesenchymal transition.JOURNAL OF PATHOLOGY,242(4),409-420. |
| MLA | Hao, Mingang,et al."HIC1 loss promotes prostate cancer metastasis by triggering epithelial - mesenchymal transition".JOURNAL OF PATHOLOGY 242.4(2017):409-420. |
入库方式： OAI收割
来源：上海营养与健康研究所
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