Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies
文献类型：期刊论文
| 作者 | Lawn, Rebecca B.4,8; Anderson, Emma L.4; Suderman, Matthew1,4; Simpkin, Andrew J.4; Gaunt, Tom R.1,4; Relton, Caroline L.1,4; Howe, Laura D.1,4; Anderson, Emma L.1; Teschendorff, Andrew E.2,3,7; Widschwendter, Martin2 |
| 刊名 | HUMAN MOLECULAR GENETICS
 |
| 出版日期 | 2018 |
| 卷号 | 27期号:7页码:1301-1308 |
| 关键词 | AML1-ETO E protein AETFC acute myeloid leukemia dendritic cell |
| ISSN号 | 0964-6906 |
| DOI | 10.1093/hmg/ddy036 |
| 文献子类 | Article |
| 英文摘要 | Psychosocial adversity in childhood (e.g. abuse) and low socioeconomic position (SEP) can have significant lasting effects on social and health outcomes. DNA methylation-based biomarkers are highly correlated with chronological age; departures of methylation-predicted age from chronological age can be used to define a measure of age acceleration, which may represent a potential biological mechanism linking environmental exposures to later health outcomes. Using data from two cohorts of women Avon Longitudinal Study of Parents and Children, (ALSPAC), N = 989 and MRC National Survey of Health and Development, NSHD, N = 773), we assessed associations of SEP, psychosocial adversity in childhood (parental physical or mental illness or death, parental separation, parental absence, sub-optimal maternal bonding, sexual, emotional and physical abuse and neglect) and a cumulative score of these psychosocial adversity measures, with DNA methylation age acceleration in adulthood (measured in peripheral blood at mean chronological ages 29 and 47 in ALSPAC and buccal cells at age 53 in NSHD). Sexual abuse was strongly associated with age acceleration in ALSPAC (sexual abuse data were not available in NSHD), e.g. at the 47-year time point sexual abuse associated with a 3.41 years higher DNA methylation age (95% CI 1.53 to 5.29) after adjusting for childhood and adulthood SEP. No associations were observed between low SEP, any other psychosocial adversity measure or the cumulative psychosocial adversity score and age acceleration. DNA methylation age acceleration is associated with sexual abuse, suggesting a potential mechanism linking sexual abuse with adverse outcomes. Replication studies with larger sample sizes are warranted. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | LIFE SOCIAL-ENVIRONMENT ; DNA METHYLATION ; CARDIOVASCULAR-DISEASE ; SEXUAL-MATURATION ; CHILDREN ALSPAC ; RISK ; MORTALITY ; OBESITY ; HEALTH ; ABUSE |
| 语种 | 英语 |
| WOS记录号 | WOS:000429009400015 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/989]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol, Avon, England; 2.UCL, Dept Womens Canc, London, England; 3.UCL, UCL Canc Inst, London, England; 4.MRC Integrat Epidemiol Unit, Bristol, Avon, England; 5.UCL, MRC Unit Lifelong Hlth & Ageing, London, England; 6.Natl Univ Ireland, Insight Ctr Data Analyt, Galway, Ireland, 7.Shanghai Inst Biol Sci, CAS Max Planck Partner Inst Computat Biol, Shanghai 200031, Peoples R China; 8.Sch Expt Psychol, Bristol, Avon, England; |
| 推荐引用方式 GB/T 7714 | Lawn, Rebecca B.,Anderson, Emma L.,Suderman, Matthew,et al. Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies[J]. HUMAN MOLECULAR GENETICS,2018,27(7):1301-1308. |
| APA | Lawn, Rebecca B..,Anderson, Emma L..,Suderman, Matthew.,Simpkin, Andrew J..,Gaunt, Tom R..,...&,.(2018).Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.HUMAN MOLECULAR GENETICS,27(7),1301-1308. |
| MLA | Lawn, Rebecca B.,et al."Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies".HUMAN MOLECULAR GENETICS 27.7(2018):1301-1308. |
入库方式： OAI收割
来源：上海营养与健康研究所
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