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Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice

文献类型：期刊论文

作者Wei, Siying1; Zhao, Jingyu1; Bai, Meijuan1; Li, Chenchen1; Zhang, Lingling1; Chen, Yan1,2; Li, Chenchen2; ,
刊名NUTRITION & METABOLISM
出版日期2019
卷号16期号:1页码:60
关键词Diabetes Intermittent fasting Fasting-mimicking diet Calorie restriction Insulin sensitivity
ISSN号2212-8778
DOI10.1186/s12986-019-0388-x
文献子类Article
英文摘要Background Calorie restriction (CR) has been well proved to be a powerful tool to improve metabolic health associated with aging; and many types of CR have been proposed. Intermittent CR has become a trend in recent years due to its better compliance than continuous CR every day. However, there are few studies that directly compare the interventional activity of intermittent CR vs continuous CR in metabolic disorders such as diabetes. Methods In this study, we analyzed two protocols of intermittent CR with the calorie-matched continuous CR in two diabetic mouse models including db/db and streptozotocin-treated mice. Intermittent CR was carried out by a fasting-mimicking diet (FMD, with 30% calorie intake of the control per day) for 2 days or 5 days (i.e., 2-5 or 5-9 regimes followed by free eating for 5 or 9 days respectively). Results In the two diabetic mouse models, both intermittent CR and continuous CR significantly reduced fasting blood glucose level and improved insulin sensitivity. However, intermittent CR performed significantly better than continuous CR in improving glycemic control and insulin sensitivity in db/db mice. In addition, intermittent CR improved the glucose homeostasis of the db/db mice without causing loss of body weight. Analyses with the pancreatic islets reveal that intermittent CR profoundly elevated the number of insulin-positive cells in both diabetic mouse models. Conclusions Our study indicated that both intermittent CR and continuous CR can lower fasting blood glucose level in the diabetic mice, while intermittent CR is better than the latter in improving glucose homeostasis in db/db mice.
学科主题Nutrition & Dietetics
WOS关键词DIET ; REGENERATION
语种英语
WOS记录号WOS:000483053900001
出版者BMC
版本出版稿
源URL[http://202.127.25.144/handle/331004/991]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China,
推荐引用方式
GB/T 7714		 Wei, Siying,Zhao, Jingyu,Bai, Meijuan,et al. Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice[J]. NUTRITION & METABOLISM,2019,16(1):60.
APA Wei, Siying.,Zhao, Jingyu.,Bai, Meijuan.,Li, Chenchen.,Zhang, Lingling.,...&,.(2019).Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice.NUTRITION & METABOLISM,16(1),60.
MLA Wei, Siying,et al."Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice".NUTRITION & METABOLISM 16.1(2019):60.

入库方式： OAI收割

来源：上海营养与健康研究所

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