A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Meniere's disease
文献类型：期刊论文
| 作者 | Li, Lin2; An, Lifeng2; Wang, YanShu3; Kong, XiangYin1; Huang, Tao1; , |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2017 |
| 卷号 | 12期号:8页码:e0182592 |
| 关键词 | cancer-associated cachexia adipose tissue loss long noncoding RNAs adipogenesis HuR |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0182592 |
| 文献子类 | Article |
| 英文摘要 | As a chronic illness derived from hair cells of the inner ear, Meniere's disease (MD) negatively influences the quality of life of individuals and leads to a number of symptoms, such as dizziness, temporary hearing loss, and tinnitus. The complete identification of novel genes related to MD would help elucidate its underlying pathological mechanisms and improve its diagnosis and treatment. In this study, a network-based method was developed to identify novel MD-related genes based on known MD-related genes. A human protein-protein interaction (PPI) network was constructed using the PPI information reported in the STRING database. A classic ranking algorithm, the random walk with restart (RWR) algorithm, was employed to search for novel genes using known genes as seed nodes. To make the identified genes more reliable, a series of screening tests, including a permutation test, an interaction test and an enrichment test, were designed to select essential genes from those obtained by the RWR algorithm. As a result, several inferred genes, such as CD4, NOTCH2 and IL6, were discovered. Finally, a detailed biological analysis was performed on fifteen of the important inferred genes, which indicated their strong associations with MD. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | HUMAN ENDOLYMPHATIC SAC ; PROTEIN-PROTEIN INTERACTIONS ; SENSORINEURAL HEARING-LOSS ; SHORTEST-PATH ALGORITHM ; INTRATYMPANIC GENTAMICIN TREATMENT ; INNER-EAR ; OXIDATIVE STRESS ; T-CELLS ; CHEMOKINE CXCL9 ; LIPID-PEROXIDATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000406998800049 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/993]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China, 2.Jilin Univ, China Japan Union Hosp, Dept Otorhinolaryngol & Head & Neck, Changchun, Jilin, Peoples R China; 3.Jilin Univ, Dept Anesthesia, Hosp 1, Changchun, Jilin, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Lin,An, Lifeng,Wang, YanShu,et al. A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Meniere's disease[J]. PLOS ONE,2017,12(8):e0182592. |
| APA | Li, Lin,An, Lifeng,Wang, YanShu,Kong, XiangYin,Huang, Tao,&,.(2017).A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Meniere's disease.PLOS ONE,12(8),e0182592. |
| MLA | Li, Lin,et al."A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Meniere's disease".PLOS ONE 12.8(2017):e0182592. |
入库方式： OAI收割
来源：上海营养与健康研究所
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