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Immune imbalance is associated with the development of preeclampsia

文献类型：期刊论文

作者Ma, Yu5,6; Zhang, Jin5,6; Ruan, Cheng-Chao5,6; Gao, Ping-Jin2,3,4,5,6; Ye, Yao1; Ruan, Cheng-Chao2,3,4; ,
刊名MEDICINE
出版日期2019
卷号98期号:14页码:e15080
关键词cytokines inflammation macrophage monocytes preeclampsia
ISSN号0025-7974
DOI10.1097/MD.0000000000015080
文献子类Article
英文摘要Preeclampsia (PE) is characterized by hypertension and proteinuria. It affects about 5% to 8% of pregnancies and causes maternal and perinatal mortality and morbidity. The immune imbalance and excessive inflammatory response play vital roles in the pathogenesis of PE. In this study, we performed a case-control study to investigate the levels of cytokines, chemokines and adhesion molecules in serum and placenta of normal pregnant and PE women by Bio-Plex multiplex immunoassay and immunohistochemistry. In addition, we explored the phenotypes of monocyte and macrophage in peripheral blood and placentas in 2 groups by using flow cytometry analysis and immunohistochemistry. Our results show that pro-inflammatory factors, including interleukin-1 beta (IL-1 beta), IL-6, IL-7, IL-8, IL-17a, monocyte chemotactic protein 1 (MCP -1), and macrophage inflammatory protein 1 beta (MIP-1 beta) were significantly increased in serum of women with PE compared with controls. In addition, we detected that IL-1 beta, IL-6, and MCP-1 were also increased in placentas of women with PE. We further revealed that peripheral blood monocytes showed a pro-inflammatory M1-like phenotype in women with PE. Consistently, M1 macrophage infiltration was increased in placenta of women with PE compared to that of normal pregnant women. Our results demonstrated that immune imbalance promotes an inflammatory state during PE and it may be a potential therapeutic possibility for the management of PE.
学科主题General & Internal Medicine
WOS关键词MACROPHAGE POLARIZATION ; MONOCYTES ; PREGNANCY ; HYPERTENSION ; CYTOKINES ; PATHOPHYSIOLOGY
语种英语
WOS记录号WOS:000467323600051
出版者LIPPINCOTT WILLIAMS & WILKINS
版本出版稿
源URL[http://202.127.25.144/handle/331004/994]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Obstet & Gynecol, Munich, Germany;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Vasc Biol, Shanghai, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China,
5.Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Sch Med,Shanghai Key Lab Hypertens,Dept Hypertens, Shanghai, Peoples R China;
6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Ma, Yu,Zhang, Jin,Ruan, Cheng-Chao,et al. Immune imbalance is associated with the development of preeclampsia[J]. MEDICINE,2019,98(14):e15080.
APA Ma, Yu.,Zhang, Jin.,Ruan, Cheng-Chao.,Gao, Ping-Jin.,Ye, Yao.,...&,.(2019).Immune imbalance is associated with the development of preeclampsia.MEDICINE,98(14),e15080.
MLA Ma, Yu,et al."Immune imbalance is associated with the development of preeclampsia".MEDICINE 98.14(2019):e15080.

入库方式： OAI收割

来源：上海营养与健康研究所

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