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The Identification and Analysis of mRNA-lncRNA-miRNA Cliques From the Integrative Network of Ovarian Cancer

文献类型：期刊论文

作者Zhou, You2,3,4; Zheng, Xiao2,3,4; Xu, Bin2,3,4; Hu, Wenwei2; Jiang, Jingting2,3,4; Huang, Tao1; ,
刊名FRONTIERS IN GENETICS
出版日期2019
卷号10期号:-页码:751
关键词variance inflation factor regression mRNA-lncRNA-miRNA cliques regulatory network construct ovarian cancer functional regulator
ISSN号0021-9738
DOI10.3389/fgene.2019.00751
文献子类Article
英文摘要Ovarian cancer is one of the leading causes of cancer mortality in women. Since little clinical symptoms were shown in the early period of ovarian cancer, most patients were found in phases III-IV or with abdominal metastasis when diagnosed. The lack of effective early diagnosis biomarkers makes ovarian cancer difficult to screen. However, in essence, the fundamental problem is we know very little about the regulatory mechanisms during tumorigenesis of ovarian cancer. There are emerging regulatory factors, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), which have played important roles in cancers. Therefore, we analyzed the RNA-seq profiles of 407 ovarian cancer patients. An integrative network of 20,424 coding RNAs (mRNAs), 10,412 lncRNAs, and 742 miRNAs were construed with variance inflation factor (VIF) regression method. The mRNA-lncRNA-miRNA cliques were identified from the network and analyzed. Such promising cliques showed significant correlations with survival and stage of ovarian cancer and characterized the complex sponge regulatory mechanism, suggesting their contributions to tumorigenicity. Our results provided novel insights of the regulatory mechanisms among mRNAs, lncRNAs, and miRNAs and highlighted several promising regulators for ovarian cancer detection and treatment.
学科主题Genetics & Heredity
WOS关键词LONG NONCODING RNA ; MULTIDRUG-RESISTANCE ; TUMOR-SUPPRESSOR ; GENE ; PROMOTES ; GROWTH ; PROLIFERATION ; EXPRESSION ; INVASION ; MIGRATION
语种英语
WOS记录号WOS:000482068000001
出版者FRONTIERS MEDIA SA
版本出版稿
源URL[http://202.127.25.144/handle/331004/996]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Inst Biol Sci CAS, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China,
2.Soochow Univ, Affifiated Hosp 3, Dept Tumor Biol Treatment, Changzhou, Peoples R China;
3.Jiangsu Engn Res Ctr Tumor Immunotherapy, Changzhou, Peoples R China;
4.Soochow Univ, Inst Cell Therapy, Changzhou, Peoples R China;
推荐引用方式
GB/T 7714		 Zhou, You,Zheng, Xiao,Xu, Bin,et al. The Identification and Analysis of mRNA-lncRNA-miRNA Cliques From the Integrative Network of Ovarian Cancer[J]. FRONTIERS IN GENETICS,2019,10(-):751.
APA Zhou, You.,Zheng, Xiao.,Xu, Bin.,Hu, Wenwei.,Jiang, Jingting.,...&,.(2019).The Identification and Analysis of mRNA-lncRNA-miRNA Cliques From the Integrative Network of Ovarian Cancer.FRONTIERS IN GENETICS,10(-),751.
MLA Zhou, You,et al."The Identification and Analysis of mRNA-lncRNA-miRNA Cliques From the Integrative Network of Ovarian Cancer".FRONTIERS IN GENETICS 10.-(2019):751.

入库方式： OAI收割

来源：上海营养与健康研究所

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