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FER promotes cell migration via regulating JNK activity

文献类型：期刊论文

作者Li, Ping2,3; Ma, Zhiwei2,3; Yu, Yun2,3; Zhou, Yanfeng2; Song, Haiyun2,3; Hu, Xingjie1; ,
刊名CELL PROLIFERATION
出版日期2019
卷号52期号:5页码:e12656
关键词cancer metastasis cell migration Fer FER JNK signalling
ISSN号0960-7722
DOI10.1111/cpr.12656
文献子类Article
英文摘要Objectives Cell migration has a key role in cancer metastasis, which contributes to drug resistance and tumour recurrence. Better understanding of the mechanisms involved in this process will potentially reveal new drug targets for cancer therapy. Fer is a non-receptor protein tyrosine kinase aberrantly expressed in various human cancers, whereas its role in tumour progression remains elusive. Materials and Methods Transgenic flies and epigenetic analysis were employed to investigate the role of Drosophila Fer (FER) in cell migration and underlying mechanisms. Co-immunoprecipitation assay was used to monitor the interaction between FER and Drosophila JNK (Bsk). The conservation of Fer in regulating JNK signalling was explored in mammalian cancer and non-cancer cells. Results Overexpression of FER triggered cell migration and activated JNK signalling in the Drosophila wing disc. Upregulation and downregulation in the basal activity of Bsk exacerbated and eliminated FER-mediated migration, respectively. In addition, loss of FER blocked signal transduction of the JNK pathway. Specifically, FER interacted with and promoted the activity of Bsk, which required both the kinase domain and the C-terminal of Bsk. Lastly, Fer regulated JNK activities in mammalian cells. Conclusions Our study reveals FER as a positive regulator of JNK-mediated cell migration and suggests its potential role as a therapeutic target for cancer metastasis.
学科主题Cell Biology
WOS关键词TUMOR INVASION ; MATRIX METALLOPROTEINASES ; CANCER METASTASIS ; DROSOPHILA ; KINASE ; ACTIVATION ; EXPRESSION ; MORPHOGENESIS ; MECHANISMS ; PATHWAY
语种英语
WOS记录号WOS:000474008000001
出版者WILEY
版本出版稿
源URL[http://202.127.25.144/handle/331004/999]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Guangzhou Med Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China,
2.Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China;
3.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Ping,Ma, Zhiwei,Yu, Yun,et al. FER promotes cell migration via regulating JNK activity[J]. CELL PROLIFERATION,2019,52(5):e12656.
APA Li, Ping.,Ma, Zhiwei.,Yu, Yun.,Zhou, Yanfeng.,Song, Haiyun.,...&,.(2019).FER promotes cell migration via regulating JNK activity.CELL PROLIFERATION,52(5),e12656.
MLA Li, Ping,et al."FER promotes cell migration via regulating JNK activity".CELL PROLIFERATION 52.5(2019):e12656.

入库方式： OAI收割

来源：上海营养与健康研究所

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