GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity
文献类型：期刊论文
| 作者 | Sun, Qianqian1,3; Yuan, Fan1,3; Yuan, Ruixue1,3; Ren, Decheng1,3; Zhu, Yuhao1,3; Bi, Yan1,3; Hu, Jiaxin1,3; Guo, Zhenming1,3; Xu, Fei1,3; Niu, Weibo1,3 |
| 刊名 | MEDICINE
 |
| 出版日期 | 2019 |
| 卷号 | 98期号:19页码:e15456 |
| 关键词 | GRIA1 GRIK4 GRM7 major depressive disorder response venlafaxine |
| ISSN号 | 0025-7974 |
| DOI | 10.1097/MD.0000000000015456 |
| 文献子类 | Article |
| 英文摘要 | Venlafaxine is one of commonly prescribed antidepressants for major depressive disorder (MDD). Accumulated evidence implicates the involvement of glutamatergic receptors in the pathophysiology of MDD and antidepressant treatment. By using 193 MDD patients who have been taking venlafaxine for 6 weeks, we investigated whether single nucleotide polymorphisms (SNPs) in glutamate ionotropic receptor kainate type subunit 4 (GRIK4), glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) and glutamate metabotropic receptor 7 (GRM7) were associated with treatment response. 14 SNPs were selected randomly depended on association studies. Efficacy of treatment was determined by 17-item of Hamilton Rating Scale. Allele and genotype frequencies were compared between responders and non-responders. After adjusting by the false discovery rate (FDR), rs6589847 and rs56275759 in GRIK4 and rs9870680 in GRM7 showed associating with venlafaxine treatment response at week 6. (FDR: P=.018, P=.042, and P=.040, respectively). Our results indicated that genetic variants in the GRIK4 and GRM7 may associate with the treatment response in MDD patients treated by venlafaxine. |
| 学科主题 | General & Internal Medicine |
| WOS关键词 | MAJOR DEPRESSIVE DISORDER ; TREATMENT-RESISTANT DEPRESSION ; CITALOPRAM TREATMENT ; ASSOCIATION ; POLYMORPHISMS ; VARIANTS ; SCHIZOPHRENIA ; SYMPTOMS ; EFFICACY ; XR |
| 语种 | 英语 |
| WOS记录号 | WOS:000473112000028 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1001]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Shanghai Inst Mental Hlth, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Sun, Qianqian,Yuan, Fan,Yuan, Ruixue,et al. GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity[J]. MEDICINE,2019,98(19):e15456. |
| APA | Sun, Qianqian.,Yuan, Fan.,Yuan, Ruixue.,Ren, Decheng.,Zhu, Yuhao.,...&,.(2019).GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity.MEDICINE,98(19),e15456. |
| MLA | Sun, Qianqian,et al."GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity".MEDICINE 98.19(2019):e15456. |
入库方式： OAI收割
来源：上海营养与健康研究所
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