Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3
文献类型：期刊论文
| 作者 | Xu, Xi1; Zhu, Xiao-Peng1; Bai, Jin-Yun1; Xia, Pu1; Lu, Yan1,3; Li, Xiao-Ying1,3; Gao, Xin1,3; Xia, Pu3; Li, Yu2; , |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2019 |
| 卷号 | 33期号:6页码:7289-7300 |
| 关键词 | BBR mitochondrial beta-OX LCAD |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.201802316R |
| 文献子类 | Article |
| 英文摘要 | Berberine (BBR) shows promising effects in the treatment of nonalcoholic fatty liver disease (NAFLD) by influencing various metabolic aspects. Inhibition of mitochondrial beta-oxidation (beta-OX) participates in the pathogenesis of NAFLD. Silent mating-type information regulation 2 homolog 3 (SIRT3) has been reported to regulate mitochondrial beta-OX by deacetylating its substrate, long-chain acyl-coenzyme A dehydrogenase (LCAD). This study aimed to explore whether BBR can promote mitochondrial beta-OX and the role of SIRT3 as well as the mechanisms underlying the effects of BBR on hepatic lipid metabolism in mice fed a high-fat diet (HFD). BBR can significantly improve systematic and hepatic lipid metabolism in HFD-fed mice. Metabolomics analysis revealed that beta-OX was inhibited in HFD-induced mice, as indicated by the reduced production of short and medium carbon chain acyl-carnitines, the activated form of free fatty acids, via beta-OX, which was reversed by BBR intervention. Exploration of the mechanism found that BBR intervention reversed the down-regulation of SIRT3 and decreased the LCAD hyperacetylation level in HFD-fed mice. SIRT3 knockout (KO) mice were used to identify the role of SIRT3 in the BBR's influence of beta-OX. The beneficial effects of BBR on systemic and hepatic metabolism were profoundly attenuated in KO mice. Moreover, the promotive effect of BBR on beta-OX in HFD-induced mice was partially abolished in KO mice. These results suggested that BBR alleviates HFD-induced inhibition of fatty acid beta-OX partly through SIRT3-mediated LCAD deacetylation, which may provide a novel mechanism and support BBR as a promising therapeutic for NAFLD.-Xu, X., Zhu, X.-P., Bai, J.-Y., Xia, P., Li, Y., Lu, Y., Li, X.-Y., Gao, X. Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3. |
| 学科主题 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| WOS关键词 | ACID OXIDATION ; HEPATIC STEATOSIS ; DISEASE ; ACYLCARNITINES ; ACETYLATION ; CARNITINE ; MECHANISM ; MITOCHONDRIA ; DYSFUNCTION ; KINASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000476114200051 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1003]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Affiliated Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Chinese Acad Sci, Shanghai, Peoples R China, 3.Fudan Inst Metab Dis, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Xi,Zhu, Xiao-Peng,Bai, Jin-Yun,et al. Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3[J]. FASEB JOURNAL,2019,33(6):7289-7300. |
| APA | Xu, Xi.,Zhu, Xiao-Peng.,Bai, Jin-Yun.,Xia, Pu.,Lu, Yan.,...&,.(2019).Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.FASEB JOURNAL,33(6),7289-7300. |
| MLA | Xu, Xi,et al."Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3".FASEB JOURNAL 33.6(2019):7289-7300. |
入库方式： OAI收割
来源：上海营养与健康研究所
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