Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity
文献类型：期刊论文
| 作者 | Liu, Chu-Xiao2; Li, Xiang2; Jiang, Shan2; Gao, Xiang2; Guo, Si-Kun2; Zhou, Zhaocai2; Chen, Ling-Ling2,4; Nan, Fang3; Xue, Wei3; Dong, Kaige3 |
| 刊名 | CELL
 |
| 出版日期 | 2019 |
| 卷号 | 177期号:4页码:865-+ |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2019.03.046 |
| 文献子类 | Article |
| 英文摘要 | Circular RNAs (circRNAs) produced from backsplicing of exons of pre-mRNAs are widely expressed, but current understanding of their functions is limited. These RNAs are stable in general and are thought to have unique structural conformations distinct from their linear RNA cognates. Here, we show that endogenous circRNAs tend to form 16-26 bp imperfect RNA duplexes and act as inhibitors of double-stranded RNA (dsRNA)-activated protein kinase (PKR) related to innate immunity. Upon poly(I:C) stimulation or viral infection, circRNAs are globally degraded by RNase L, a process required for PKR activation in early cellular innate immune responses. Augmented PKR phosphorylation and circRNA reduction are found in peripheral blood mononuclear cells (PBMCs) derived from patients with autoimmune disease systemic lupus erythematosus (SLE). Importantly, overexpression of the dsRNA-containing circRNA in PBMCs or T cells derived from SLE can alleviate the aberrant PKR activation cascade, thus providing a connection between circRNAs and SLE. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | INDUCIBLE GENE-EXPRESSION ; PROTEIN-KINASE ; READ ALIGNMENT ; REVEALS ; RECOGNITION ; DISEASE ; BRAIN ; MOUSE ; CELLS ; DECAY |
| 语种 | 英语 |
| WOS记录号 | WOS:000466843000009 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1004]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Mol Rheumatol,Shanghai Inst Nutr & Hlth, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Univ Chinese Acad Sci,Shanghai Inst Biochem & Cel, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Univ Chinese Acad Sci,Shanghai Inst Nutr & Hlth, CAS Key Lab Computat Biol,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China; 5.Shanghai Jiao Tong Univ, China Australia Ctr Personalized Immunol, Renji Hosp, Shanghai Inst Rheumatol,Sch Med, Shanghai, Peoples R China; 6.Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Coll Med, Ctr Autoimmune Genom & Etiol,Dept Pediat, Cincinnati, OH USA, |
| 推荐引用方式 GB/T 7714 | Liu, Chu-Xiao,Li, Xiang,Jiang, Shan,et al. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity[J]. CELL,2019,177(4):865-+. |
| APA | Liu, Chu-Xiao.,Li, Xiang.,Jiang, Shan.,Gao, Xiang.,Guo, Si-Kun.,...&,.(2019).Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.CELL,177(4),865-+. |
| MLA | Liu, Chu-Xiao,et al."Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity".CELL 177.4(2019):865-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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