Heavy-Ion Carbon Radiation Regulates Long Non-Coding RNAs in Cervical Cancer HeLa Cells
文献类型：期刊论文
| 作者 | Yang, Zhi1,2,3; Gu, Qingying1,2,3; Wang, Ying1,2; Liu, Bo1,2; Ruan, Jing1,2; Jia, Renbing1,2; Ge, Shengfang1,2; Zhou, Guangming4; Shao, Chunlin5; , |
| 刊名 | JOURNAL OF CANCER
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:21页码:5022-5030 |
| 关键词 | Heavy ion carbon X-ray Gene Therapy LncRNA Cervical Cancer |
| ISSN号 | 1837-9664 |
| DOI | 10.7150/jca.30846 |
| 文献子类 | Article |
| 英文摘要 | Improving the effects of radiotherapy, such as heavy ion radiation, is currently a research priority for oncotherapy. Long non-coding RNAs (lncRNAs) are a subtype of noncoding RNAs involved in the therapeutic response to tumor radiotherapy. However, little is known about the variations in lncRNAs that occur after heavy ion radiation therapy. In this study, we established two kinds of Agilent Human lncRNA arrays and examined the effects of heavy ion radiation and X-ray irradiation on HeLa cells. We compared the differences in lncRNA expression (>=2-fold changes) between cells treated with the two types of radiation and control cells and identified 504 lncRNAs and 285 mRNAs that were differentially expressed. Among these lncRNAs, TCONS-00009910 was the most highly up-regulated lncRNA, while NONHSAT060631 was the most down-regulated lncRNA in both groups. To validate these sequencing data, RT-PCR was performed, and similar findings were obtained. GO and KEGG pathway analyses were employed to probe the potential functions of the affected lncRNAs. Numerous lncRNAs were changed after radiation exposure, showing that they may have important functions in the response to tumour radiotherapy. The present findings may help to elucidate the mechanism by which lncRNAs affect the clinical responses of cancer to radiation and may provide potential diagnostic and therapeutic targets for cancer therapy. |
| 学科主题 | Oncology |
| WOS关键词 | EXPRESSION ; SURVIVAL ; RBE |
| 语种 | 英语 |
| WOS记录号 | WOS:000484111400002 |
| 出版者 | IVYSPRING INT PUBL |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1008]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Ophthalmol, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China; 2.Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai 200011, Peoples R China; 3.Univ Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci,Chinese Acad Sci, Shanghai 200031, Peoples R China; 4.Soochow Univ, Sch Radiat Medicat & Protect, Dept Radiat Biol, Suzhou 215123, Peoples R China; 5.Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yang, Zhi,Gu, Qingying,Wang, Ying,et al. Heavy-Ion Carbon Radiation Regulates Long Non-Coding RNAs in Cervical Cancer HeLa Cells[J]. JOURNAL OF CANCER,2019,10(21):5022-5030. |
| APA | Yang, Zhi.,Gu, Qingying.,Wang, Ying.,Liu, Bo.,Ruan, Jing.,...&,.(2019).Heavy-Ion Carbon Radiation Regulates Long Non-Coding RNAs in Cervical Cancer HeLa Cells.JOURNAL OF CANCER,10(21),5022-5030. |
| MLA | Yang, Zhi,et al."Heavy-Ion Carbon Radiation Regulates Long Non-Coding RNAs in Cervical Cancer HeLa Cells".JOURNAL OF CANCER 10.21(2019):5022-5030. |
入库方式： OAI收割
来源：上海营养与健康研究所
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