Effects of dietary nucleotide supplementation on growth in infants: a meta-analysis of randomized controlled trials
文献类型：期刊论文
| 作者 | Wang, Lanfang1; Mu, Shu1; Xu, Xiaoyan1; Shi, Zhexi1; Shen, Li2; , |
| 刊名 | EUROPEAN JOURNAL OF NUTRITION
 |
| 出版日期 | 2019 |
| 卷号 | 58期号:3页码:1213-1221 |
| 关键词 | Nucleotides Meta-analysis Growth Infant formula |
| ISSN号 | 1436-6207 |
| DOI | 10.1007/s00394-018-1640-2 |
| 文献子类 | Article |
| 英文摘要 | PurposeDietary nucleotides are thought to be conditionally essential nutrients in infancy. However, studies have reported inconsistent findings regarding the association between nucleotide supplementation and infant physical growth. We conducted this meta-analysis to examine the efficacy of nucleotide supplementation of infant formula in promoting early infant growth.MethodsRandomized controlled trials that evaluated the association between nucleotide supplementation and infant growth through June 2017 were included. Study quality was assessed using the Cochrane Collaboration's Risk of Bias tool. Standardized mean differences (SMD) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using Q and I-2 tests.ResultsNucleotide supplementation significantly increased the rate of weight gain (SMD 0.26; 95% CI 0.06-0.47), but had no effect on weight (SMD -0.16; 95% CI -0.55-0.23), weight Z score (SMD, -0.42; 95% CI -1.64-0.81), length (SMD 0.01; 95% CI -0.18-0.21) and length Z score (SMD 0.15; 95% CI -0.10-0.40). Occipitofrontal head circumference (OFC) at 7-8 weeks (SMD 0.30; 95% CI 0.10-0.50) and the rate of OFC gain (SMD 0.34; 95% CI 0.09-0.58) were significantly improved with nucleotide supplementation, whereas, 16- and 20-week OFC values did not differ.ConclusionsOur meta-analysis indicated that nucleotide supplementation can increase the rate of weight gain, OFC and rate of OFC gain; however, we cannot conclude that it affects weight, weight Z score, length or length Z score. Large-scale randomized controlled trials of long-term nucleotide supplementation are needed to reach definitive conclusions. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | FORMULA-FED INFANTS ; COGNITIVE FUNCTION ; SMALL-INTESTINE ; FATTY-ACIDS ; NUCLEOSIDES ; MATURATION ; PROLIFERATION ; INTELLIGENCE ; IMMUNE ; LIPIDS |
| 语种 | 英语 |
| WOS记录号 | WOS:000466922700026 |
| 出版者 | SPRINGER HEIDELBERG |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1010]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tongji Univ, Inst Nutr & Hlth Food, Sch Med, Shanghai 200092, Peoples R China; 2.Tongji Univ, Dept Pathogen Biol, Sch Med, Shanghai 200092, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wang, Lanfang,Mu, Shu,Xu, Xiaoyan,et al. Effects of dietary nucleotide supplementation on growth in infants: a meta-analysis of randomized controlled trials[J]. EUROPEAN JOURNAL OF NUTRITION,2019,58(3):1213-1221. |
| APA | Wang, Lanfang,Mu, Shu,Xu, Xiaoyan,Shi, Zhexi,Shen, Li,&,.(2019).Effects of dietary nucleotide supplementation on growth in infants: a meta-analysis of randomized controlled trials.EUROPEAN JOURNAL OF NUTRITION,58(3),1213-1221. |
| MLA | Wang, Lanfang,et al."Effects of dietary nucleotide supplementation on growth in infants: a meta-analysis of randomized controlled trials".EUROPEAN JOURNAL OF NUTRITION 58.3(2019):1213-1221. |
入库方式： OAI收割
来源：上海营养与健康研究所
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