Distinct genomic alterations in prostate cancer of African American men.
文献类型：期刊论文
| 作者 | Dobi, Albert1,2; Petrovics, Gyorgy1,2; Li, Hua1,2; Young, Denise1,2; Tan, Shyh-Han1,2; Chen, Yongmei1,2; Rosner, Inger L.1,2; Cullen, Jennifer1,2; Srivastava, Shiv1,2; Xiao, Qingyu3 |
| 刊名 | CANCER RESEARCH
 |
| 出版日期 | 2018 |
| 卷号 | 78期号:16页码:33-34 |
| ISSN号 | 0008-5472 |
| DOI | 10.1158/1538-7445.PRCA2017-A018 |
| 文献子类 | Meeting Abstract |
| 英文摘要 | Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-beta) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Follow-up of 36 LEPR loci identified 3 maternal loci (rs10889567, rs1137101 and rs3762274) associated with fasting glucose, these 3 fetal loci associated with fasting insulin and HOMA1-IR, as well as these 3 maternal-fetal loci combinations associated with HOMA2-beta. We also demonstrated association of maternal locus rs7554485 with HOMA2-beta and HOMA2-IR, maternal locus rs10749754 with fasting glucose, fetal locus rs10749754 with HOMA2-IR. However, these associations were no longer statistically significant after Bonferroni correction. In conclusion, our results first revealed multiple associations between maternal and fetal LEPR common variants and gestational glycemic traits. These associations did not survive Bonferroni correction. These corrections are overly conservative for association studies. We therefore believe the influence of these nominally significant variants on gestational glycometabolism will be confirmed by additional studies. |
| 学科主题 | Oncology |
| 语种 | 英语 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| WOS记录号 | WOS:000441803800036 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1015]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.USUHS, Ctr Prostate Dis Res, Dept Surg, Bethesda, MD USA; 2.WRNMMC, Bethesda, MD USA; 3.Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China; 4.Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China; 5.NCI, Canc Biomarkers Res Grp, Canc Prevent Div, Bethesda, MD 20892 USA; 6.CytoTest Inc, Rockville, MD USA; 7.Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA; 8.Joint Pathol Ctr, Silver Spring, MD USA; 9.Harvard Massachusetts Inst Technol Div, Childrens Hosp Informat Program, Boston, MA USA, |
| 推荐引用方式 GB/T 7714 | Dobi, Albert,Petrovics, Gyorgy,Li, Hua,et al. Distinct genomic alterations in prostate cancer of African American men.[J]. CANCER RESEARCH,2018,78(16):33-34. |
| APA | Dobi, Albert.,Petrovics, Gyorgy.,Li, Hua.,Young, Denise.,Tan, Shyh-Han.,...&,.(2018).Distinct genomic alterations in prostate cancer of African American men..CANCER RESEARCH,78(16),33-34. |
| MLA | Dobi, Albert,et al."Distinct genomic alterations in prostate cancer of African American men.".CANCER RESEARCH 78.16(2018):33-34. |
入库方式： OAI收割
来源：上海营养与健康研究所
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