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Autophagy in neurodegenerative diseases: pathogenesis and therapy

文献类型：期刊论文

作者Guo, Fang1,2; Le, Weidong1,2,3; Liu, Xinyao3; Cai, Huaibin4; Le, Weidong5; ,
刊名BRAIN PATHOLOGY
出版日期2018
卷号28期号:1页码:3-13
ISSN号1015-6305
关键词autophagy neurodegenerative diseases protein aggregation
DOI10.1111/bpa.12545
文献子类Review
英文摘要The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy, as major intracellular machinery for degrading aggregated proteins and damaged organelles, has been reported to be involved in the occurrence of pathological changes in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. In this review, we summarize most recent research progress in this topic and provide a new perspective regarding autophagy regulation on the pathogenesis of neurodegenerative diseases. Finally, we discuss the signaling molecules in autophagy-related pathways as therapeutic targets for the treatment of these diseases.
学科主题Neurosciences & Neurology ; Pathology
WOS关键词AMYOTROPHIC-LATERAL-SCLEROSIS ; ENDOPLASMIC-RETICULUM STRESS ; ALZHEIMERS-DISEASE ; PARKINSONS-DISEASE ; ALPHA-SYNUCLEIN ; MOUSE MODEL ; AMYLOID-BETA ; HUNTINGTONS-DISEASE ; LYSOSOMAL DEGRADATION ; DAMAGED MITOCHONDRIA
语种英语
出版者WILEY
WOS记录号WOS:000418357100001
版本出版稿
源URL[http://202.127.25.144/handle/331004/1019]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol & Neurogen Lab, Shanghai 200025, Peoples R China;
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China;
3.Dalian Med Univ, Affiliated Hosp 1, Clin Res Ctr Neurol Dis, Dalian 116011, Peoples R China;
4.NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA;
5.Dalian Med Univ, Affiliated Hosp 1, Collaborat Innovat Ctr Brain Sci, Dalian 116011, Peoples R China,
推荐引用方式
GB/T 7714		 Guo, Fang,Le, Weidong,Liu, Xinyao,et al. Autophagy in neurodegenerative diseases: pathogenesis and therapy[J]. BRAIN PATHOLOGY,2018,28(1):3-13.
APA Guo, Fang,Le, Weidong,Liu, Xinyao,Cai, Huaibin,Le, Weidong,&,.(2018).Autophagy in neurodegenerative diseases: pathogenesis and therapy.BRAIN PATHOLOGY,28(1),3-13.
MLA Guo, Fang,et al."Autophagy in neurodegenerative diseases: pathogenesis and therapy".BRAIN PATHOLOGY 28.1(2018):3-13.

入库方式： OAI收割

来源：上海营养与健康研究所

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