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USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP

文献类型：期刊论文

作者Liao, Keman1; Zhou, Sunhai1; Lin, Yingying1; Chen, Xi2; Wang, Chen3; Cao, Lu4; Chen, Jiayi4; Xu, Cheng4; ,
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
出版日期2019
卷号15期号:4页码:738-748
关键词Breast cancer AEP USP17 Deubiquitination ERK
ISSN号1449-2288
DOI10.7150/ijbs.30106
文献子类Article
英文摘要Ubiquitin-specific protease 17 (USP17), a novel member of deubiquitinase, is reported to play essential roles in several solid tumors. However, the expression and function of USP17 in breast cancer tumorigenesis remains ambiguity. Here we found that the mRNA level of USP17 was lower in breast cancer tissues than normal tissues. Meanwhile, higher USP17 level was detected in normal epithelial cell MCF-10A and a less-malignant cell MCF-7 than malignant cell line MDA-MB-231. Inhibition of USP17 in MCF7 cells enhanced tumorigenesis and tumor growth while overexpression of USP17 in malignant MDA-MB-231 cells reduced its tumorigenesis and growth ability in vitro and in vivo. Further study revealed that USP17 interacted with and deubiquitinated Asparaginyl endopeptidase (AEP), resulting in decreased protein levels of AEP. Moreover, knockdown of AEP inhibited breast cancer tumorigenesis and growth in vitro and in vivo through the inactivation of ERK signaling. Taken together, our works indicate that USP17 deubiquitinates AEP, down-regulates its protein level, and inhibits breast cancer tumorigenesis through disturbing ERK signaling. Thus, our data suggests that USP17 is a potential tumor suppressor in breast cancer and AEP is a promising target in breast cancer therapy.
学科主题Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS关键词LEGUMAIN EXPRESSION ; ASPARAGINE ENDOPEPTIDASE ; ENZYME USP17 ; UBIQUITIN ; CLONING ; CHAINS
语种英语
WOS记录号WOS:000467209800002
出版者IVYSPRING INT PUBL
版本出版稿
源URL[http://202.127.25.144/handle/331004/1022]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Neurosurg, Shanghai 200127, Peoples R China;
2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China;
3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China;
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Radiat Oncol, Shanghai 200025, Peoples R China,
推荐引用方式
GB/T 7714		 Liao, Keman,Zhou, Sunhai,Lin, Yingying,et al. USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(4):738-748.
APA Liao, Keman.,Zhou, Sunhai.,Lin, Yingying.,Chen, Xi.,Wang, Chen.,...&,.(2019).USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(4),738-748.
MLA Liao, Keman,et al."USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.4(2019):738-748.

入库方式： OAI收割

来源：上海营养与健康研究所

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