Regulation of embryonic haematopoietic multipotency by EZH1
文献类型：期刊论文
| 作者 | Vo, Linda T. l1,2,3,4; Kinney, Melissa A.1,2,3; Barragan, Jessica1,2,3; Sousa, Patricia M.1,2,3; Jha, Deepak K.1,2,3; Han, Areum1,2,3; Cesana, Marcella1,2,3; Daley, George Q.1,2,3,4; Orkin, Stuart H.2,3,4; Liu, Xin5 |
| 刊名 | NATURE
 |
| 出版日期 | 2018 |
| 卷号 | 553期号:7689页码:506-+ |
| 关键词 | dioxin endothelial cell apoptosis EP3 p38 MAPK Bcl-2 |
| ISSN号 | 0028-0836 |
| DOI | 10.1038/nature25435 |
| 文献子类 | Article |
| 英文摘要 | All haematopoietic cell lineages that circulate in the blood of adult mammals derive from multipotent haematopoietic stem cells (HSCs) 1. By contrast, in the blood of mammalian embryos, lineage-restricted progenitors arise first, independently of HSCs, which only emerge later in gestation2,3. As best defined in the mouse, 'primitive' progenitors first appear in the yolk sac at 7.5 days post-coitum2,3. Subsequently, erythroid-myeloid progenitors that express fetal haemoglobin4, as well as fetal lymphoid progenitors5, develop in the yolk sac and the embryo proper, but these cells lack HSC potential. Ultimately, 'definitive' HSCs with long-term, multilineage potential and the ability to engraft irradiated adults emerge at 10.5 days post-coitum from arterial endothelium in the aorta-gonad-mesonephros and other haemogenic vasculature3. The molecular mechanisms of this reverse progression of haematopoietic ontogeny remain unexplained. We hypothesized that the definitive haematopoietic program might be actively repressed in early embryogenesis through epigenetic silencing6, and that alleviating this repression would elicit multipotency in otherwise lineage-restricted haematopoietic progenitors. Here we show that reduced expression of the Polycomb group protein EZH1 enhances multi-lymphoid output from human pluripotent stem cells. In addition, Ezh1 deficiency in mouse embryos results in precocious emergence of functional definitive HSCs in vivo. Thus, we identify EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | PLURIPOTENT STEM-CELLS ; MOUSE EMBRYO ; DEFINED FACTORS ; BLOOD-CELLS ; CHROMATIN ; LINEAGE ; ENDOTHELIUM ; PROGENITORS ; RESISTANCE ; LEUKEMIA |
| 语种 | 英语 |
| WOS记录号 | WOS:000423971100041 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1025]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Boston Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA; 2.Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA; 3.Dana Farber Canc Inst, Boston, MA 02115 USA; 4.Harvard Med Sch, Boston, MA 02115 USA; 5.Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Childrens Med Ctr, Res Inst, Dallas, TX USA; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China; 7.Beth Israel Deaconess Med Ctr, Dept Pathol, 330 Brookline Ave, Boston, MA 02215 USA; 8.Howard Hughes Med Inst, Boston, MA 02115 USA; 9.Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA, |
| 推荐引用方式 GB/T 7714 | Vo, Linda T. l,Kinney, Melissa A.,Barragan, Jessica,et al. Regulation of embryonic haematopoietic multipotency by EZH1[J]. NATURE,2018,553(7689):506-+. |
| APA | Vo, Linda T. l.,Kinney, Melissa A..,Barragan, Jessica.,Sousa, Patricia M..,Jha, Deepak K..,...&,.(2018).Regulation of embryonic haematopoietic multipotency by EZH1.NATURE,553(7689),506-+. |
| MLA | Vo, Linda T. l,et al."Regulation of embryonic haematopoietic multipotency by EZH1".NATURE 553.7689(2018):506-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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