Predominant patterns of splicing evolution on human, chimpanzee and macaque evolutionary lineages
文献类型：期刊论文
| 作者 | Xiong, Jieyi1,2; Jiang, Xi1; Gao, Yang1; Sun, Jing1; Huang, Shuyun1; Lowenstein, Elijah D.2; Ditsiou, Angeliki3,4; Lowenstein, Elijah D.5; Huang, Shuyun6; Khaitovich, Philipp7,8,9 |
| 刊名 | HUMAN MOLECULAR GENETICS
 |
| 出版日期 | 2018 |
| 卷号 | 27期号:8页码:1474-1485 |
| 关键词 | C-3 photosynthesis C-4 photosynthesis chlorophyll fluorescence cold tolerance genotype difference light response curves quantum yield temperature response curves |
| ISSN号 | 0964-6906 |
| DOI | 10.1093/hmg/ddy058 |
| 文献子类 | Article |
| 英文摘要 | Although splicing is widespread and evolves rapidly among species, the mechanisms driving this evolution, as well as its functional implications, are not yet fully understood. We analyzed the evolution of splicing patterns based on transcriptome data from five tissues of humans, chimpanzees, rhesus macaques and mice. In total, 1526 exons and exon sets from 1236 genes showed significant splicing differences among primates. More than 60% of these differences represent constitutive-to-alternative exon transitions while an additional 25% represent changes in exon inclusion frequency. These two dominant evolutionary patterns have contrasting conservation, regulation and functional features. The sum of these features indicates that, despite their prevalence, constitutive-to-alternative exon transitions do not substantially contribute to long-term functional transcriptome changes. Conversely, changes in exon inclusion frequency appear to be functionally relevant, especially for changes taking place in the brain on the human evolutionary lineage. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | PROTEIN-INTERACTION NETWORKS ; DIVERGENCE TIMES ; MECHANISMS ; GENOMES ; TISSUES ; BRAIN ; DATES |
| 语种 | 英语 |
| WOS记录号 | WOS:000429490700013 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1028]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Partner Inst Computat Biol, Shanghai 200031, Peoples R China; 2.Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany; 3.Univ Dundee, JBC WTB Bioctr, Dundee DD1 5EH, Scotland; 4.Univ Sussex, JMS Bldg, Brighton BN1 9QG, E Sussex, England; 5.Free Univ Berlin, D-14195 Berlin, Germany; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 7.Skolkovo Inst Sci & Technol, Skolkovo 143025, Russia; 8.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xiong, Jieyi,Jiang, Xi,Gao, Yang,et al. Predominant patterns of splicing evolution on human, chimpanzee and macaque evolutionary lineages[J]. HUMAN MOLECULAR GENETICS,2018,27(8):1474-1485. |
| APA | Xiong, Jieyi.,Jiang, Xi.,Gao, Yang.,Sun, Jing.,Huang, Shuyun.,...&,.(2018).Predominant patterns of splicing evolution on human, chimpanzee and macaque evolutionary lineages.HUMAN MOLECULAR GENETICS,27(8),1474-1485. |
| MLA | Xiong, Jieyi,et al."Predominant patterns of splicing evolution on human, chimpanzee and macaque evolutionary lineages".HUMAN MOLECULAR GENETICS 27.8(2018):1474-1485. |
入库方式： OAI收割
来源：上海营养与健康研究所
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