Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production
文献类型：期刊论文
| 作者 | Wang, Zhizhang1,2; Yin, Weijie1,2; Zhu, Lizhen1,2; Li, Jia1,2; Yao, Yikun1,2; Chen, Feifei1,2; Sun, Mengmeng1,2; Zhang, Jiayuan1,2; Shen, Nan1,2; Chang, Xing1,2 |
| 刊名 | IMMUNITY
 |
| 出版日期 | 2018 |
| 卷号 | 49期号:1页码:80-+ |
| ISSN号 | 1074-7613 |
| 关键词 | celastrol NLRP3 inflammasome inflammatory disease |
| DOI | 10.1016/j.immuni.2018.05.008 |
| 文献子类 | Article |
| 英文摘要 | Iron deposition is frequently observed in human autoinflammatory diseases, but its functional significance is largely unknown. Here we showed that iron promoted proinflammatory cytokine expression in T cells, including GM-CSF and IL-2, via regulating the stability of an RNA-binding protein PCBP1. Iron depletion or Pcbp1 deficiency in T cells inhibited GM-CSF production by attenuating Csf2 3' untranslated region (UTR) activity and messenger RNA stability. Pcbp1 deficiency or iron uptake blockade in autoreactive T cells abolished their capacity to induce experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis. Mechanistically, intracellular iron protected PCBP1 protein from caspase-mediated proteolysis, and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 3' UTRs. Our study suggests that iron accumulation can precipitate autoimmune diseases by promoting proinflammatory cytokine production. RNA-binding protein-mediated iron sensing may represent a simple yet effective means to adjust the inflammatory response to tissue homeostatic alterations. |
| 学科主题 | Immunology |
| WOS关键词 | FACTOR MESSENGER-RNA ; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; MULTIPLE-SCLEROSIS ; IN-VIVO ; B-CELL ; GM-CSF ; AUTOIMMUNE ENCEPHALOMYELITIS ; POSTTRANSCRIPTIONAL CONTROL ; SELECTIVE-INHIBITION ; GENE-EXPRESSION |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000438949100013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1031]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.SJTUSM, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai 200031, Peoples R China; 3.Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA, |
| 推荐引用方式 GB/T 7714 | Wang, Zhizhang,Yin, Weijie,Zhu, Lizhen,et al. Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production[J]. IMMUNITY,2018,49(1):80-+. |
| APA | Wang, Zhizhang.,Yin, Weijie.,Zhu, Lizhen.,Li, Jia.,Yao, Yikun.,...&,.(2018).Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.IMMUNITY,49(1),80-+. |
| MLA | Wang, Zhizhang,et al."Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production".IMMUNITY 49.1(2018):80-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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