Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity
文献类型：期刊论文
| 作者 | Liu, Manman1; Wu, Ping1; Zhang, Xiaoyan1; Jiang, Gengru1; Huang, Xinfang1; Liu, Junli2; Hao, Shumeng2; Xiao, Yichuan2; , |
| 刊名 | CLINICAL RHEUMATOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 37期号:10页码:2675-2684 |
| 关键词 | Disease activity EOMES Interferon-gamma Interferon-inducible genes Systemic lupus erythematosus TBX21 |
| ISSN号 | 0770-3198 |
| DOI | 10.1007/s10067-018-4138-7 |
| 文献子类 | Article |
| 英文摘要 | Increased IFN-gamma levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-gamma, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-time PCR was used to assess the mRNA expression of IFNG, type II IFN-inducible genes (IRF1, GBP1, CXCL9, CXCL10, and SERPING1, which are used for the type II IFN score), type I IFN-inducible genes (IRF7, MX1, ISG15, and ISG20, which are used for the type I IFN score), TBX21, and EOMES in peripheral blood mononuclear cells. Flow cytometry was used to measure the IFN-gamma levels in lymphocytes. The mRNA levels of type II IFN-inducible genes, IFNG, TBX21, and EOMES were significantly higher in SLE patients than those in HDs. Similarly, the percentages of IFN-gamma-producing cells in lymphocytes and their subsets in SLE patients were significantly increased. Linear regression indicated that IFNG expression levels and type II IFN scores were positively correlated with anti-double-stranded DNA autoantibody levels and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Compared with patients with low type I IFN scores, patients with high type I IFN scores showed increased type II IFN scores and SLEDAI scores. Type II IFN scores were positively associated with type I IFN scores. The IFN-gamma signaling pathway is activated in SLE patients and may be considered an index of disease activity. IFN-gamma, together with type I IFNs, promotes the pathogenesis of SLE. |
| 学科主题 | Rheumatology |
| WOS关键词 | BLOOD MONONUCLEAR-CELLS ; GENE-EXPRESSION ; REVISED CRITERIA ; INDUCIBLE GENES ; ACTIVITY INDEX ; AUTOIMMUNITY ; CLASSIFICATION ; ASSOCIATION ; INDUCTION ; BLOCKADE |
| 语种 | 英语 |
| WOS记录号 | WOS:000444749500010 |
| 出版者 | SPRINGER LONDON LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1035]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Renal & Rheumatol, Shanghai 200092, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Manman,Wu, Ping,Zhang, Xiaoyan,et al. Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity[J]. CLINICAL RHEUMATOLOGY,2018,37(10):2675-2684. |
| APA | Liu, Manman.,Wu, Ping.,Zhang, Xiaoyan.,Jiang, Gengru.,Huang, Xinfang.,...&,.(2018).Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity.CLINICAL RHEUMATOLOGY,37(10),2675-2684. |
| MLA | Liu, Manman,et al."Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity".CLINICAL RHEUMATOLOGY 37.10(2018):2675-2684. |
入库方式： OAI收割
来源：上海营养与健康研究所
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