The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis
文献类型:期刊论文
作者 | Liu, Panpan1,2; He, Yijing1,2; Kuang, Yehong1,2; Chen, Wangqing1,2; Li, Jie1,2; Chen, Mingliang1,2; Zhang, Jianglin1,2; Su, Juan1,2; Zhao, Shuang1,2; Chen, Menglin1,2 |
刊名 | JOURNAL OF DERMATOLOGICAL SCIENCE
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出版日期 | 2018 |
卷号 | 89期号:3页码:233-240 |
关键词 | CTLA-4 Psoriasis T cells Mouse model of psoriasis |
ISSN号 | 0923-1811 |
DOI | 10.1016/j.jdermsci.2017.11.007 |
文献子类 | Article |
英文摘要 | Background: Psoriasis is a chronic inflammatory disease characterized by epidermal hyperplasia and increased T cell infiltration. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a key factor that affects T cell function and immune response. However, whether the expression of CTLA-4 affects the severity of psoriasis is still unknown. Objective: The aim of the project was to investigate the correlation between the expression of CTLA-4 and the severity of psoriasis. Methods: The plasma soluble CTLA-4 levels and membrane CTLA-4 expression were measured by enzyme-linked immunosorbent assay and immunohistochemistry analysis in mild, moderate and severe psoriasis patients, respectively. Imiquimod-induced mouse model of psoriasis was treated with CTLA-4 immunoglobulin fusion protein (CTLA-4Ig) or anti-CTLA-4 antibody. Epidermal thickness and infiltrating CD3+ T cell counts were evaluated. Results: The plasma soluble CTLA-4 levels had no significant difference among mild, moderate, and severe patients (p > 0.05). However, the membrane CTLA-4 expression in skin was significantly higher in mild psoriasis patients compared to moderate and severe psoriasis patients (17652.86 +/- 18095.66 vs 6901.36 +/- 4400.77 vs 3970.24 +/- 5509.15, p < 0.001). Furthermore, in imiquimod-induced mouse model of psoriasis, the results showed that mimicking CTLA-4 function improved the skin phenotype and reduced epidermal thickness (172.87 +/- 28.25 vs 245.87 +/- 36.61 p.m, n = 6, p < 0.01) as well as infiltrating CD3+ T cell counts (5.09 +/- 3.45 vs 13.45 +/- 4.70, p < 0.01) compared to control group. However, blocking CTLA-4 function aggregated the skin phenotype including enhanced epidermal thickness and infiltrating CD3+ T cell counts compared to control group. Conclusion: These results indicated that the expression of mCTLA-4 in skin lesion inversely correlated with the severity of psoriasis and CTLA-4 might play a critical role in the disease severity of psoriasis. (C) 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved. |
学科主题 | Dermatology |
WOS关键词 | T-CELL-ACTIVATION ; IMMUNE DYSREGULATION ; SOLUBLE FORM ; AUTOIMMUNE-DISEASE ; REGULATORY T ; CTLA-4 ; SERUM ; VULGARIS ; COSTIMULATION ; POLYMORPHISMS |
语种 | 英语 |
WOS记录号 | WOS:000429514100004 |
出版者 | ELSEVIER IRELAND LTD |
版本 | 出版稿 |
源URL | [http://202.127.25.144/handle/331004/1036] ![]() |
专题 | 中国科学院上海生命科学研究院营养科学研究所 |
作者单位 | 1.Cent S Univ, XiangYa Hosp, Dept Dermatol, 87 XiangYa Rd, Changsha 410008, Hunan, Peoples R China; 2.Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai Inst Immunol,Inst Med Sci,Chinese Acad S, Shanghai, Peoples R China; 4.Huazhong Univ Sci & Technol, Affiliated Union Hosp, Dept Dermatol, Tongji Med Coll, Wuhan, Hubei, Peoples R China, |
推荐引用方式 GB/T 7714 | Liu, Panpan,He, Yijing,Kuang, Yehong,et al. The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2018,89(3):233-240. |
APA | Liu, Panpan.,He, Yijing.,Kuang, Yehong.,Chen, Wangqing.,Li, Jie.,...&,.(2018).The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis.JOURNAL OF DERMATOLOGICAL SCIENCE,89(3),233-240. |
MLA | Liu, Panpan,et al."The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis".JOURNAL OF DERMATOLOGICAL SCIENCE 89.3(2018):233-240. |
入库方式: OAI收割
来源:上海营养与健康研究所
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