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The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spil expression

文献类型：期刊论文

作者Yu, Shan-He2; Zhang, Fan2; Chen, Yi2; Jin, Yi2; Huang, Qiu-Hua2; Zhu, Jiang2; Xu, Peng-Fei2; Liu, Ting-Xi2,3,4; Zhu, Kang-Yong3,4; Dong, Mei3,4
刊名BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
出版日期2018
卷号1861期号:2页码:106-116
关键词Histone demethylase Jmjd3 Myelopoiesis Spil Zebrafish
ISSN号1874-9399
DOI10.1016/j.bbagrm.2017.12.009
文献子类Article
英文摘要The histone demethylase Jmjd3 plays a critical role in cell lineage specification and differentiation at various stages of development. However, its function during normal myeloid development remains poorly understood. Here, we carried out a systematic in vivo screen of epigenetic factors for their function in hematopoiesis and identified Jmjd3 as a new epigenetic factor that regulates myelopoiesis in zebrafish. We demonstrated that jmjd3 was essential for zebrafish primitive and definitive myelopoiesis, knockdown of jmjd3 suppressed the myeloid commitment and enhanced the erythroid commitment. Only overexpression of spil but not the other myeloid regulators rescued the myeloid development in jmjd3 morphants. Furthermore, preliminary mechanistic studies demonstrated that Jmjd3 could directly bind to the spil regulatory region to alleviate the repressive H3K27me3 modification and activate spil expression. Thus, our studies highlight that Jmjd3 is indispensable for early zebrafish myeloid development by promoting spil expression.
学科主题Biochemistry & Molecular Biology ; Biophysics
WOS关键词GENE-EXPRESSION ; STEM-CELLS ; TRANSCRIPTION FACTOR ; H3K27 DEMETHYLASE ; DEFICIENT MICE ; PU.1 GENE ; IN-VIVO ; LINEAGE ; HEMATOPOIESIS ; DIFFERENTIATION
语种英语
WOS记录号WOS:000427211400005
出版者ELSEVIER SCIENCE BV
版本出版稿
源URL[http://202.127.25.144/handle/331004/1038]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Harvard Med Sch, Div Hematol yOncol, Harvard Stem Cell Inst, Boston Childrens Hosp,Pediat Hematol Oncol,Dana F, Boston, MA 02115 USA;
2.Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, State Key Lab Med Genom,Shanghai Inst Hematol,Col, Shanghai 200025, Peoples R China;
3.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China;
5.Tongji Univ, Sch Life Sci & Technol, Dept Bioinfonnat, Shanghai 200092, Peoples R China;
6.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sinofrench Res Ctr Life Sci & Genom, Sch Med, Shanghai 200025, Peoples R China;
7.Huazhong Univ Sci & Technol, Tongji Hosp, Tongii Med Coll, Wuhan 430030, Hubei, Peoples R China;
8.Harvard Univ, Harvard Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA;
9.Harvard Med Sch, Stem Cell Program, Harvard Stem Cell Inst, Boston Childrens Hosp,Pediat Hematol Oncol,Dana F, Boston, MA 02115 USA;
10.Howard Hughes Med Inst, Boston, MA 02115 USA,
推荐引用方式
GB/T 7714		 Yu, Shan-He,Zhang, Fan,Chen, Yi,et al. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spil expression[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2018,1861(2):106-116.
APA Yu, Shan-He.,Zhang, Fan.,Chen, Yi.,Jin, Yi.,Huang, Qiu-Hua.,...&,.(2018).The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spil expression.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1861(2),106-116.
MLA Yu, Shan-He,et al."The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spil expression".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1861.2(2018):106-116.

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来源：上海营养与健康研究所

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