Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis
文献类型：期刊论文
| 作者 | Zhang, Hui2; Liu, Jing2; Qian, Qiaoxia2; Ding, Yue2; Li, Yuan2; Ma, Yanyun2; Zhou, Jingru2; Mei, Zhendong2; Chen, Xiangxiang2; Wang, Xiaofeng2,13 |
| 刊名 | CLINICAL RHEUMATOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 37期号:6页码:1605-1616 |
| ISSN号 | 0770-3198 |
| 关键词 | Ankylosing spondylitis Cumulative smoking exposure Outcomes Smoking duration Smoking intensity |
| DOI | 10.1007/s10067-018-4016-3 |
| 文献子类 | Article |
| 英文摘要 | The objective of this study was to systemically and comprehensively evaluate the associations between smoking and disease outcomes in patients with ankylosing spondylitis (AS). Information on smoking, clinical features, and sociodemographic characteristics was collected by a questionnaire administered directly to the patient. Group differences were analyzed by t test or chi-square test. Logistic regression analysis was conducted with the Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), C-reactive protein, and erythrocyte sedimentation rate as the dependent variables and different stratification of smoking duration, smoking intensity, and cumulative smoking as independent variables. In order to compare our results with previous studies, meta-analysis was performed to calculate standardized mean difference (SMD) for relationship between outcomes and smoking status. A total of 1178 AS patients were analyzed. Compared with non-smokers, the risk of having active disease (BASDAI >= 4) was higher in patients who smoked at least 15 years, or 15 cigarettes per day, or 15 pack-years (OR = 1.70 [1.06, 2.73], 1.75 [1.08, 2.82], and 1.97 [1.06, 3.67], respectively); and smokers had increasing risk of BASDAI >= 4 with increasing years of smoking, or cigarettes per day, or pack-years (p(-trend) = 0.010, 0.008 and 0.006, respectively). The risk of having active disease was higher in patients who smoked at least 15 cigarettes per day or 15 pack-years (OR = 1.74 [1.06, 2.84] and 2.89 [1.56, 5.35], respectively), with increasing number of cigarettes per day and pack-years. Smokers had an increased risk of BASFI >= 4 (p(-trend) = 0.040 and 0.007, respectively). By meta-analysis, current, former and ever smokers had significantly higher BASDAI (SMD = 0.34 [0.18, 0.48], 0.10 [0.01, 0.19], and 0.27 [0.20, 0.34], respectively) and BASFI (SMD = 0.35 [0.16, 0.55], 0.30 [0.22, 0.39], and 0.35 [0.21, 0.50], respectively) compared to non-smokers. Smoking is a risk factor for greater disease activity and worse functioning in AS patients. |
| 学科主题 | Rheumatology |
| WOS关键词 | QUALITY-OF-LIFE ; RHEUMATOID-ARTHRITIS ; CIGARETTE-SMOKING ; AXIAL SPONDYLOARTHRITIS ; ALCOHOL-CONSUMPTION ; BACK-PAIN ; LONG-TERM ; PREVALENCE ; METAANALYSIS ; ADALIMUMAB |
| 语种 | 英语 |
| 出版者 | SPRINGER LONDON LTD |
| WOS记录号 | WOS:000431943200020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1039]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China; 2.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn, Shanghai, Peoples R China; 3.Changhai Hosp, Div Rheumatol & Immunol, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Rheumatol & Immunol, Shanghai, Peoples R China; 5.Wuxi Peoples Hosp, Div Rheumatol & Immunol, Wuxi, Jiangsu, Peoples R China; 6.Taizhou Peoples Hosp, Div Rheumatol, Taizhou, Jiangsu, Peoples R China; 7.Taixing Peoples Hosp, Div Rheumatol, Taizhou, Jiangsu, Peoples R China; 8.Shanghai Acad Chinese Med Sci, Guanghua Integrat Med Hosp, Inst Arthrit Res, Shanghai, Peoples R China; 9.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Div Rheumatol, Shanghai, Peoples R China; 10.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Div Rheumatol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Hui,Liu, Jing,Qian, Qiaoxia,et al. Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis[J]. CLINICAL RHEUMATOLOGY,2018,37(6):1605-1616. |
| APA | Zhang, Hui.,Liu, Jing.,Qian, Qiaoxia.,Ding, Yue.,Li, Yuan.,...&,.(2018).Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis.CLINICAL RHEUMATOLOGY,37(6),1605-1616. |
| MLA | Zhang, Hui,et al."Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis".CLINICAL RHEUMATOLOGY 37.6(2018):1605-1616. |
入库方式： OAI收割
来源：上海营养与健康研究所
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