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Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet

文献类型：期刊论文

作者Luan, Yi1; Zhang, Fang1; Cheng, Yalan1; Liu, Jun1; Huang, Rui1; Yan, Menghong1; Wang, Yuangao1; He, Zhishui1; Lai, Hejin1; Wang, Hui1
刊名NUTRIENTS
出版日期2017
卷号9期号:8页码:805
关键词hemin insulin resistance lipid metabolism hepatic steatosis
ISSN号2072-6643
DOI10.3390/nu9080805
文献子类Article
英文摘要Hemin is a breakdown product of hemoglobin. It has been reported that the injection of hemin improves lipid metabolism and insulin sensitivity in various genetic models. However, the effect of hemin supplementation in food on lipid metabolism and insulin sensitivity is still unclear, and whether hemin directly affects cellular insulin sensitivity is yet to be elucidated. Here we show that hemin enhances insulin-induced phosphorylation of insulin receptors, Akt, Gsk3 beta, FoxO1 and cytoplasmic translocation of FoxO1 in cultured primary hepatocytes under insulin-resistant conditions. Furthermore, hemin diminishes the accumulation of triglyceride and increases in free fatty acid content in primary hepatocytes induced by palmitate. Oral administration of hemin decreases body weight, energy intake, blood glucose and triglyceride levels, and improves insulin and glucose tolerance as well as hepatic insulin signaling and hepatic steatosis in male mice fed a high-fat diet. In addition, hemin treatment decreases the mRNA and protein levels of some hepatic genes involved in lipogenic regulation, fatty acid synthesis and storage, and increases the mRNA level and enzyme activity of CPT1 involved in fatty acid oxidation. These data demonstrate that hemin can improve lipid metabolism and insulin sensitivity in both cultured hepatocytes and mice fed a high-fat diet, and show the potential beneficial effects of hemin from food on lipid and glucose metabolism.
学科主题Nutrition & Dietetics
WOS关键词REV-ERB-ALPHA ; GLUCOSE-METABOLISM ; OXYGENASE SYSTEM ; MOUSE ; RATS ; ACCUMULATION ; ADIPOCYTES ; INHIBITION ; ACTIVATION ; RESISTANCE
语种英语
WOS记录号WOS:000408688100013
出版者MDPI AG
版本出版稿
源URL[http://202.127.25.144/handle/331004/1043]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Inst Nutr Sci, Shanghai Inst Biol Sci,Key Lab Nutr & Metab, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200093, Peoples R China,
推荐引用方式
GB/T 7714		 Luan, Yi,Zhang, Fang,Cheng, Yalan,et al. Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet[J]. NUTRIENTS,2017,9(8):805.
APA Luan, Yi.,Zhang, Fang.,Cheng, Yalan.,Liu, Jun.,Huang, Rui.,...&,.(2017).Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet.NUTRIENTS,9(8),805.
MLA Luan, Yi,et al."Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet".NUTRIENTS 9.8(2017):805.

入库方式： OAI收割

来源：上海营养与健康研究所

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