Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
文献类型：期刊论文
| 作者 | Liu, Ruixin2; Hong, Jie2; Gu, Yanyun2; Shi, Juan2; Zhao, Shaoqian2; Liu, Wen2; Cui, Bin2; Liang, Peiwen2; Xi, Liuqing2; Li, Wanyu2 |
| 刊名 | NATURE MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 23期号:7页码:859-+ |
| ISSN号 | 1078-8956 |
| DOI | 10.1038/nm.4358 |
| 文献子类 | Article |
| 英文摘要 | Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology ; Research & Experimental Medicine |
| WOS关键词 | Y GASTRIC BYPASS ; DIET-INDUCED OBESITY ; MONOSODIUM GLUTAMATE ; BARIATRIC SURGERY ; THETAIOTAOMICRON ; RICHNESS ; MARKERS ; GLUCOSE ; IMPACT ; GENES |
| 语种 | 英语 |
| WOS记录号 | WOS:000405180100015 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1044]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Natl Clin Res Ctr Endocrine & Metab Dis, State Key Lab Med Genomes,Ruijin Hosp, Shanghai, Peoples R China; 3.BGI Shenzhen, Shenzhen, Peoples R China; 4.Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen, Peoples R China; 5.BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intest, Shenzhen, Peoples R China; 6.BGI Shenzhen, China Natl GeneBank, Shenzhen, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China; 8.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 9.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Pancreat Dis Ctr,Dept Gen Surg, Shanghai, Peoples R China; 10.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Ruixin,Hong, Jie,Gu, Yanyun,et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention[J]. NATURE MEDICINE,2017,23(7):859-+. |
| APA | Liu, Ruixin.,Hong, Jie.,Gu, Yanyun.,Shi, Juan.,Zhao, Shaoqian.,...&,.(2017).Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.NATURE MEDICINE,23(7),859-+. |
| MLA | Liu, Ruixin,et al."Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention".NATURE MEDICINE 23.7(2017):859-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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