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Highly efficient base editing in human tripronuclear zygotes

文献类型：期刊论文

作者Zhou, Changyang5,6; Wei, Yu5; Pan, Hong5; Yang, Hui5; Sun, Yidi6; Li, Yixue1,2,4,6; Zhang, Meiling7; Sun, Yun7; Yao, Ning7; Zhong, Wanxia7
刊名PROTEIN & CELL
出版日期2017
卷号8期号:10页码:772-775
关键词Cancer stem cells epidermal growth factor receptor lung cancer microRNA
ISSN号1674-800X
DOI10.1007/s13238-017-0459-6
文献子类Letter
英文摘要Primary aldosteronism (PA) is the most common secondary cause of hypertension. The present study investigated differences in left ventricular structure and function between hypertensive patients with PA and sucjects with essential hypertension (EH). One hundred patients with PA and 100 controls with EH were matched for age, gender, and 24-h ambulatory monitoring blood pressure (BP). Left ventricular mass index (LVMI), left atrial volume index (LAVI) and ejection fraction were calculated. LV diastolic function was estimated as the ratio of the early diastolic velocities (E) from transmitral inflow to the early diastolic velocities (e') of tissue Doppler at mitral annulus. PA and EH patients had similar LV dimensions, LV wall thicknesses, LVMI and LV systolic function. PA was associated with greater impairment in diastolic function, as reflected by the lower e' (P = 0.004), higher E/e' ratio (P = 0.005) and higher LAVI (P = 0.02). The LV geometric dimensions and patterns of LV hypertrophy were similar between male patients from the PA and EH groups. However, in female patients, PA was correlated with higher LV internal dimensions (P = 0.001), higher LVMI (P = 0.04) and lower relative wall thickness (RWT, P = 0.001). Multivariate analysis showed that LV diastolic function was independently correlated with age (beta = 0.416, P < 0.001), 24-h systolic BP (beta = 0.238, P = 0.016) and serum potassium (beta = - 0.201, P = 0.036) in PA patients. In conclusion, PA appears to contribute to the impairment of LV diastolic function in both sexes as well as the higher prevalence of eccentric hypertrophy in women than in men compared with EH. Age, 24-h systolic BP and serum potassium levels are independent risk factors for LV diastolic function in PA patients.
学科主题Cell Biology
WOS关键词ONE-STEP GENERATION ; MOUSE ; MICE ; EMBRYOS ; DNA
语种英语
WOS记录号WOS:000412750000009
出版者HIGHER EDUCATION PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/1046]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China;
2.Fudan Univ, Inst Biomed Sci, Med Coll, Shanghai 200032, Peoples R China;
3.Guangxi Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning 530004, Peoples R China,
4.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, Shanghai 201203, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci,State Key Lab Neurosci,Key Lab Prim, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China;
6.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China;
7.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Shanghai Key Lab Assisted Reprod & Reprod Genet,C, Shanghai 200127, Peoples R China;
8.Shandong Univ, Ctr Reprod Med, Shandong Prov Hosp,Key Lab Reprod Endocrinol,Mini, Natl Res Ctr Assisted Reprod Technol & Reprod Gen, Jinan 250021, Shandong, Peoples R China;
推荐引用方式
GB/T 7714		 Zhou, Changyang,Wei, Yu,Pan, Hong,et al. Highly efficient base editing in human tripronuclear zygotes[J]. PROTEIN & CELL,2017,8(10):772-775.
APA Zhou, Changyang.,Wei, Yu.,Pan, Hong.,Yang, Hui.,Sun, Yidi.,...&,.(2017).Highly efficient base editing in human tripronuclear zygotes.PROTEIN & CELL,8(10),772-775.
MLA Zhou, Changyang,et al."Highly efficient base editing in human tripronuclear zygotes".PROTEIN & CELL 8.10(2017):772-775.

入库方式： OAI收割

来源：上海营养与健康研究所

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