Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice
文献类型：期刊论文
| 作者 | Liu, Wen2; Zhao, Shaoqian2; Wang, Jiqiu2; Shi, Juan2; Sun, Yingkai2; Wang, Weiqing2; Ning, Guang2; Hong, Jie2; Liu, Ruixin2; Ning, Guang1,3 |
| 刊名 | MOLECULAR NUTRITION & FOOD RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 61期号:9页码:1601082 |
| 关键词 | Adiposity GSPE Gut microbiota High-fat diet Inflammation |
| ISSN号 | 1613-4125 |
| DOI | 10.1002/mnfr.201601082 |
| 文献子类 | Article |
| 英文摘要 | Scope: Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota have been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism. Methods and results: Mice were fed a normal diet and a high-fat diet with or without GSPE (300 mg/kg body weight/day) by oral gavage for 7 weeks. Supplementation with GSPE significantly decreased plasma levels of inflammatory factors such as TNF-alpha, IL-6 and MCP-1, companied with ameliorated macrophage infiltration in epidydimal fat and liver tissues. Furthermore, GSPE also reduced epidydimal fat mass and improved insulin sensitivity. 16S rDNA analyses revealed that GSPE supplementation modulated the gut microbiota composition and certain bacteria including Clostridium XIVa, Roseburia and Prevotella. More importantly, depleting gut microbiota by antibiotics treatment abolished the beneficial effects of GSPE on inflammation and adiposity. Conclusion: Our study identifies the novel links between gut microbiota alterations and metabolic benefits by GSPE supplementation, providing possibilities for the prevention and treatment of metabolic disorders by targeting gut microbiota through a potential prebiotic agent GSPE. |
| 学科主题 | Food Science & Technology |
| WOS关键词 | NF-KAPPA-B ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; INDUCED OBESITY ; TLR5-DEFICIENT MICE ; URINARY-EXCRETION ; RICH EXTRACTS ; POLYPHENOLS ; DISEASE ; TISSUE |
| 语种 | 英语 |
| WOS记录号 | WOS:000408981500022 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1048]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Lab Endocrinol & Metab, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med,Ruijin Hosp, Shanghai Clin Ctr Endocrine & Metab Dis,China Nat, Shanghai Inst Endocrine & Metab Dis,Dept Endocrin, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Wen,Zhao, Shaoqian,Wang, Jiqiu,et al. Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2017,61(9):1601082. |
| APA | Liu, Wen.,Zhao, Shaoqian.,Wang, Jiqiu.,Shi, Juan.,Sun, Yingkai.,...&,.(2017).Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice.MOLECULAR NUTRITION & FOOD RESEARCH,61(9),1601082. |
| MLA | Liu, Wen,et al."Grape seed proanthocyanidin extract ameliorates inflammation and adiposity by modulating gut microbiota in high-fat diet mice".MOLECULAR NUTRITION & FOOD RESEARCH 61.9(2017):1601082. |
入库方式： OAI收割
来源：上海营养与健康研究所
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