Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression
文献类型：期刊论文
| 作者 | Zhu, Yi2,3; Lin, Hua V.2; Zhao, Shangang3; Deng, Yingfeng3; Gordillo, Ruth3; Ghaben, Alexandra L.3; Shao, Mengle3; Zhang, Fang3; Gupta, Rana K.3; Scherer, Philipp E.3 |
| 刊名 | DIABETES
 |
| 出版日期 | 2017 |
| 卷号 | 66期号:11页码:2789-2799 |
| 关键词 | Bacillus velezensis S3-1 Genome sequence Plant pathogens inhibition Plant promotion |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/db17-0323 |
| 文献子类 | Article |
| 英文摘要 | Transcripts of key enzymes in the Leloir pathway of galactose metabolism in mouse livers are significantly increased after chronic high-fat/high-sucrose feeding. UDP-galactose-4-epimerase (GALE) is the last enzyme in this pathway that converts UDP-galactose to UDP-glucose and was previously identified as a downstream target of the endoplasmic reticulum (ER) stress effector spliced X-box binding protein 1, suggesting an interesting cross talk between galactose and glucose metabolism in the context of hepatic ER stress and whole-body metabolic fitness. However, its specific role in glucose metabolism is not established. Using an inducible and tissue-specific mouse model, we report that hepatic overexpression of Gale increases gluconeogenesis from pyruvate and impairs glucose tolerance. Conversely, genetic reduction of Gale in liver improves glucose tolerance. Transcriptional profiling identifies trefoil factor 3 (Tff3) as one of the downstream targets of GALE. Restoration of Tff3 expression corrects glucose intolerance in Gale-overexpressing mice. These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; INTESTINAL TREFOIL FACTOR ; METABOLIC IMPROVEMENTS ; INSULIN SENSITIVITY ; ER STRESS ; GENE ; IDENTIFICATION ; GALACTOSEMIA ; RESISTANCE ; ADIPOCYTE |
| 语种 | 英语 |
| WOS记录号 | WOS:000413559100008 |
| 出版者 | AMER DIABETES ASSOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1049]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA USA; 2.Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA; 3.UT Southwestern Med Ctr, Touchstone Diabet Ctr, Dallas, TX 75390 USA; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China; 5.Lilly China Res & Dev Ctr, Shanghai, Peoples R China; 6.UT Southwestern Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX USA, |
| 推荐引用方式 GB/T 7714 | Zhu, Yi,Lin, Hua V.,Zhao, Shangang,et al. Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression[J]. DIABETES,2017,66(11):2789-2799. |
| APA | Zhu, Yi.,Lin, Hua V..,Zhao, Shangang.,Deng, Yingfeng.,Gordillo, Ruth.,...&,.(2017).Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression.DIABETES,66(11),2789-2799. |
| MLA | Zhu, Yi,et al."Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression".DIABETES 66.11(2017):2789-2799. |
入库方式： OAI收割
来源：上海营养与健康研究所
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