A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells
文献类型：期刊论文
| 作者 | Guo, Weiwei1; You, Xue1; Wang, Xiao1; Wang, Lin1; Chen, Yan1,2; You, Xue2; , |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2017 |
| 卷号 | 405期号:-页码:1-9 |
| 关键词 | PI3K Peptide Therapy Gastric cancers Mouse model |
| ISSN号 | 0304-3835 |
| DOI | 10.1016/j.canlet.2017.07.015 |
| 文献子类 | Article |
| 英文摘要 | Activation of class I Phosphoinositide 3-kinases (PI3Ks) by mutation or overexpression closely correlates with the development of various human cancers. Class I PI3Ks are heterodimers composed of p110 catalytic subunits and regulatory subunits represented by p85. PAQR3 has been found to inhibit p110 alpha activity by blocking its interaction with p85. In this study, we identified the N-terminal 6-55 amino acid residues of PAQR3 being sufficient for its interaction with p110 alpha. A synthetic peptide, P6-55, that contains the N-terminus of PAQR3 could disrupt the interactions of p110 alpha with both PAQR3 and p85. The activity of PI3K was also inhibited by P6-55, accompanied by significant inhibition of cancer cell proliferation. In a xenograft mouse model, P6-55 was able to reduce tumor growth in vivo. Furthermore, P6-55 was capable of inhibiting the elevated basal PI3K activity of H1047R, a hotspot mutation found in many types of human cancers. The cell proliferation and migration of cancer cells bearing H1047R mutation were also reduced by P6-55. In conclusion, our study provides a proof of concept that blocking the interaction of p110 alpha with p85 by a peptide can serve as a new strategy to inhibit the oncogenic activity of PI3K in cancer therapy. (C) 2017 Elsevier B.V. All rights reserved. |
| 学科主题 | Oncology |
| WOS关键词 | PHOSPHOINOSITIDE 3-KINASE P110-ALPHA ; HEPATOCELLULAR-CARCINOMA ; TUMOR-SUPPRESSOR ; BREAST-CANCER ; PAQR3 PLAYS ; MUTATIONS ; PIK3CA ; TUMORIGENESIS ; RKTG ; PROGRESSION |
| 语种 | 英语 |
| WOS记录号 | WOS:000412036200001 |
| 出版者 | ELSEVIER IRELAND LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1050]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Guo, Weiwei,You, Xue,Wang, Xiao,et al. A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells[J]. CANCER LETTERS,2017,405(-):1-9. |
| APA | Guo, Weiwei.,You, Xue.,Wang, Xiao.,Wang, Lin.,Chen, Yan.,...&,.(2017).A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells.CANCER LETTERS,405(-),1-9. |
| MLA | Guo, Weiwei,et al."A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells".CANCER LETTERS 405.-(2017):1-9. |
入库方式： OAI收割
来源：上海营养与健康研究所
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