Identification of the core regulators of the HLA I-peptide binding process
文献类型：期刊论文
| 作者 | Zhang, Yu-Hang2; Xing, Zhihao2; Huang, Tao2; Kong, Xiangyin2; Liu, Chenglin1; Wang, ShaoPeng3; Cai, Yu-Dong3; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:42768 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep42768 |
| 文献子类 | Article |
| 英文摘要 | During the display of peptide/human leukocyte antigen (HLA)-I complex for further immune recognition, the cleaved and transported antigenic peptides have to bind to HLA-I protein and the binding affinity between peptide epitopes and HLA proteins directly influences the immune recognition ability in human beings. Key factors affecting the binding affinity during the generation, selection and presentation processes of HLA-I complex have not yet been fully discovered. In this study, a new method describing the HLA class I-peptide interactions was proposed. Three hundred and forty features of HLA I proteins and peptide sequences were utilized for analysis by four candidate algorithms, screening the optimal classifier. Features derived from the optimal classifier were further selected and systematically analyzed, revealing the core regulators. The results validated the hypothesis that features of HLA I proteins and related peptides simultaneously affect the binding process, though with discrepant redundancy. Besides, the high relative ratio (16/20) of the amino acid composition features suggests the unique role of sequence signatures for the binding processes. Integrating biological, evolutionary and chemical features of both HLA I molecules and peptides, this study may provide a new perspective of the underlying mechanisms of HLA I-mediated immune reactions. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | MHC CLASS-I ; MAJOR HISTOCOMPATIBILITY COMPLEX ; AMINO-ACID-COMPOSITION ; SECONDARY STRUCTURE ; T-CELLS ; NEURAL-NETWORKS ; ANTIGEN ; PREDICTION ; MOLECULES ; PROTEIN |
| 语种 | 英语 |
| WOS记录号 | WOS:000394319800001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1051]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Chinese Acad Sci, Shanghai 200031, Peoples R China; 3.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhang, Yu-Hang,Xing, Zhihao,Huang, Tao,et al. Identification of the core regulators of the HLA I-peptide binding process[J]. SCIENTIFIC REPORTS,2017,7(-):42768. |
| APA | Zhang, Yu-Hang.,Xing, Zhihao.,Huang, Tao.,Kong, Xiangyin.,Liu, Chenglin.,...&,.(2017).Identification of the core regulators of the HLA I-peptide binding process.SCIENTIFIC REPORTS,7(-),42768. |
| MLA | Zhang, Yu-Hang,et al."Identification of the core regulators of the HLA I-peptide binding process".SCIENTIFIC REPORTS 7.-(2017):42768. |
入库方式： OAI收割
来源：上海营养与健康研究所
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