Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
文献类型：期刊论文
| 作者 | Shen, Shuhua2; Gui, Tuantuan3; Ma, Chengcheng1,4; , |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:25页码:41432-41439 |
| 关键词 | minimum-redundancy-maximum-relevance (mRMR) pancreatic cancer biomarker |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.18186 |
| 文献子类 | Article |
| 英文摘要 | The high mortality rate of pancreatic cancer makes it one of the most studied diseases among all cancer types. Many researches have been conducted to understand the mechanism underlying its emergence and pathogenesis of this disease. Here, by using minimum-redundancy-maximum-relevance (mRMR) method, we studied a set of transcriptome data of pancreatic cancer. As we gradually added features to achieve the most accurate classification results of Jackknife, a gene set of 9 genes was identified. They were NHS, SCML2, LAMC2, S100P, COL17A1, AMIGO2, PTPRR, KPNA7 and KCNN4. Through STRING 2.0 protein-protein interactions (PPIs) analysis, 40 proteins were identified in the shortest paths between genes in the gene set, 30 of them passed the permutation test, which indicated they were hubs in the background network. Those genes in the protein- protein interaction network were enriched to 37 functional modules, such as: negative regulation of transcription from RNA polymerase II promoter, negative regulation of ERK1 and ERK2 cascade and BMP signaling pathway. Our study indicated new mechanism of pancreatic cancer, suggesting potential therapeutic targets for further study. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | GENE-EXPRESSION PROFILES ; LAMININ GAMMA-2 ; IN-VITRO ; ADENOCARCINOMA ; INVASION ; S100P ; CELLS ; METASTASIS ; STATISTICS ; RECEPTOR |
| 语种 | 英语 |
| WOS记录号 | WOS:000404283700121 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1054]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China; 2.Zhejiang Prov Hosp Tradit Chinese Med, Hangzhou, Zhejiang, Peoples R China; 3.Shanghai Smartquerier Biotechnol Co Ltd, Shanghai, Peoples R China; 4.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Shen, Shuhua,Gui, Tuantuan,Ma, Chengcheng,et al. Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method[J]. ONCOTARGET,2017,8(25):41432-41439. |
| APA | Shen, Shuhua,Gui, Tuantuan,Ma, Chengcheng,&,.(2017).Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method.ONCOTARGET,8(25),41432-41439. |
| MLA | Shen, Shuhua,et al."Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method".ONCOTARGET 8.25(2017):41432-41439. |
入库方式： OAI收割
来源：上海营养与健康研究所
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