Identification of Genes Associated with Breast Cancer Metastasis to Bone on a Protein-Protein Interaction Network with a Shortest Path Algorithm
文献类型：期刊论文
| 作者 | Cai, Yu-Dong2; Zhang, Qing2; Zhang, Yu-Hang1; Huang, Tao1; Chen, Lei3; , |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 16期号:2页码:1027-1038 |
| 关键词 | breast cancer metastasis to bone breast cancer bone cancer protein-protein interaction shortest path algorithm |
| ISSN号 | 1535-3893 |
| DOI | 10.1021/acs.jproteome.6b00950 |
| 文献子类 | Article |
| 英文摘要 | Tumor metastasis is defined as the spread of tumor cells from one organ or part to another that is not directly connected to it, which significantly contributes to the progression and aggravation of tumorigenesis. Because it always involves multiple organs, the metastatic process is difficult to study in its entirety. Complete identification of the genes related to this process is an alternative way to study metastasis. In this study, we developed a computational method to identify such genes. To test our method, we selected breast cancer bone metastasis. A large network was constructed using human protein-protein interactions. On the basis of the validated genes related to breast and bone cancer, a shortest path algorithm was applied to the network to search for novel genes that may mediate breast cancer metastasis to bone. In addition, further rules constructed using the permutation FDR, the betweenness ratio, and the maxmin interaction score were also employed in the method to make the inferred genes more reliable. Eighteen putative genes were identified by the method and were extensively analyzed. The confirmation results indicate that these genes participate in metastasis. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; ACUTE BASOPHILIC LEUKEMIA ; CELL-CYCLE PROGRESSION ; WNT/BETA-CATENIN ; STEM-CELLS ; ESTROGEN-RECEPTOR ; IN-VIVO ; PROSTATE-CANCER ; LUNG-CANCER ; SIGNALING PATHWAY |
| 语种 | 英语 |
| WOS记录号 | WOS:000393539600061 |
| 出版者 | AMER CHEMICAL SOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1055]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 2.Shanghai Univ, Sch Life Sci, Shanghai 200111, Peoples R China; 3.Shanghai Maritime Univ, Coll Informat Engn, Shanghai 201306, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Cai, Yu-Dong,Zhang, Qing,Zhang, Yu-Hang,et al. Identification of Genes Associated with Breast Cancer Metastasis to Bone on a Protein-Protein Interaction Network with a Shortest Path Algorithm[J]. JOURNAL OF PROTEOME RESEARCH,2017,16(2):1027-1038. |
| APA | Cai, Yu-Dong,Zhang, Qing,Zhang, Yu-Hang,Huang, Tao,Chen, Lei,&,.(2017).Identification of Genes Associated with Breast Cancer Metastasis to Bone on a Protein-Protein Interaction Network with a Shortest Path Algorithm.JOURNAL OF PROTEOME RESEARCH,16(2),1027-1038. |
| MLA | Cai, Yu-Dong,et al."Identification of Genes Associated with Breast Cancer Metastasis to Bone on a Protein-Protein Interaction Network with a Shortest Path Algorithm".JOURNAL OF PROTEOME RESEARCH 16.2(2017):1027-1038. |
入库方式： OAI收割
来源：上海营养与健康研究所
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