No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population
文献类型：期刊论文
| 作者 | Ren, Decheng1,2; Xu, Fei1,2; Bi, Yan1,2; Niu, Weibo1,2; Zhang, Rui1,2; Hu, Jiaxin1,2; Guo, Zhenming1,2; Cao, Yanfei1,2; Huang, Xiaoye1,2; Wu, Xi1,2 |
| 刊名 | PSYCHIATRIC GENETICS
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:4页码:159-160 |
| 关键词 | Biodegradation Fumonisin B1 Bacterial consortium Enzymatic detoxification Metabolites |
| ISSN号 | 0955-8829 |
| DOI | 10.1097/YPG.0000000000000175 |
| 文献子类 | Article |
| 英文摘要 | The Smoothened receptor (SMO) belongs to the Class Frizzled of the G protein-coupled receptor (GPCR) superfamily, constituting a key component of the Hedgehog signalling pathway. Here we report the crystal structure of the multi-domain human SMO, bound and stabilized by a designed tool ligand TC114, using an X-ray free-electron laser source at 2.9 angstrom. The structure reveals a precise arrangement of three distinct domains: a seven-transmembrane helices domain (TMD), a hinge domain (HD) and an intact extracellular cysteine-rich domain (CRD). This architecture enables allosteric interactions between the domains that are important for ligand recognition and receptor activation. By combining the structural data, molecular dynamics simulation, and hydrogen-deuterium-exchange analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD play a central role in transmitting the signal employing a unique GPCR activation mechanism, distinct from other multi-domain GPCRs. |
| 学科主题 | Genetics & Heredity ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000404880700005 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1060]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Bio X Ctr, 1954 Huashan Rd, Shanghai 200030, Peoples R China; 2.Shanghai Jiao Tong Univ, Shanghai Inst Mental Hlth, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China; Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ren, Decheng,Xu, Fei,Bi, Yan,et al. No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population[J]. PSYCHIATRIC GENETICS,2017,27(4):159-160. |
| APA | Ren, Decheng.,Xu, Fei.,Bi, Yan.,Niu, Weibo.,Zhang, Rui.,...&,.(2017).No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population.PSYCHIATRIC GENETICS,27(4),159-160. |
| MLA | Ren, Decheng,et al."No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population".PSYCHIATRIC GENETICS 27.4(2017):159-160. |
入库方式： OAI收割
来源：上海营养与健康研究所
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