No association detected between seven common variants in the CDKALI gene and gestational glycemic traits
文献类型：期刊论文
| 作者 | Ju, Hongfang2; Lin, Rong3; Sun, Yuantian3; Zeng, Liangliang3; Su, Zhenyu3; Yuan, Ziyu1,4,5; Jin, Li1,4,5; Jin, Li6; , |
| 刊名 | MOLECULAR AND CELLULAR PROBES
 |
| 出版日期 | 2017 |
| 卷号 | 34期号:-页码:64-67 |
| 关键词 | Gestational glycemic traits CDKALI Genetic variants |
| ISSN号 | 0890-8508 |
| DOI | 10.1016/j.mcp.2017.05.003 |
| 文献子类 | Article |
| 英文摘要 | Elevated plasma glucose levels in pregnancy increase adverse pregnancy outcomes. Cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) has been shown to be involved in insulin secretion in pancreatic cells. In this study, we investigated the impact of genetic variants in CDKALI on plasma glucose, insulin values, 13 cell function and insulin resistance in the fasted state as well as plasma glucose 1 h after the consumption of a 50-g oral glucose load between 24 and 28 weeks of pregnancy among 929 unrelated pregnant Han Chinese women. Seven common variants previously reported to associate with diabetes were genotyped. Insulin resistance and beta cell function were assessed by homeostasis model assessment. The genetic impacts were analyzed using analysis of variance and analysis of covariance. The results showed that there was no significant association between any of the seven variants and those gestational glycemic traits. Therefore, this study suggests that the seven common variants in CDKALI are not significant factors for the variations of several gestational glycemic traits in the Han Chinese population. However, further well-designed studies with larger sample size, more ethnic groups and more CDICAL1 variants are required to validate the association between CDICAL1 and gestational glycemic traits. (C) 2017 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Cell Biology |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; DIABETES-MELLITUS ; LOCI ; SUSCEPTIBILITY ; REPLICATION ; POPULATION ; DISEASE ; RISK |
| 语种 | 英语 |
| WOS记录号 | WOS:000407528700010 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1061]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China; 2.Taizhou Peoples Hosp, Dept Gynaecol & Obstet, Taizhou, Jiangsu, Peoples R China; 3.Hainan Med Coll, Dept Biol, Haikou 571199, Hainan, Peoples R China; 4.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China; 5.Fudan Taizhou Inst Hlth Sci, Taizhou, Jiangsu, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ju, Hongfang,Lin, Rong,Sun, Yuantian,et al. No association detected between seven common variants in the CDKALI gene and gestational glycemic traits[J]. MOLECULAR AND CELLULAR PROBES,2017,34(-):64-67. |
| APA | Ju, Hongfang.,Lin, Rong.,Sun, Yuantian.,Zeng, Liangliang.,Su, Zhenyu.,...&,.(2017).No association detected between seven common variants in the CDKALI gene and gestational glycemic traits.MOLECULAR AND CELLULAR PROBES,34(-),64-67. |
| MLA | Ju, Hongfang,et al."No association detected between seven common variants in the CDKALI gene and gestational glycemic traits".MOLECULAR AND CELLULAR PROBES 34.-(2017):64-67. |
入库方式： OAI收割
来源：上海营养与健康研究所
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