Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis
文献类型：期刊论文
| 作者 | Shen, Guosong4; He, Pingya4; Mao, Yingying5; Li, Peipei6; Luh, Frank1,7; Liu, Xiyong7; Dings, Guohui3; Yen, Yun2; , |
| 刊名 | JOURNAL OF BREAST CANCER
 |
| 出版日期 | 2017 |
| 卷号 | 20期号:2页码:132-141 |
| 关键词 | Biomarkers Breast neoplasms Prognosis Uridine-cytidine kinase 2 |
| ISSN号 | 1738-6756 |
| DOI | 10.4048/jbc.2017.20.2.132 |
| 文献子类 | Article |
| 英文摘要 | Purpose: Uridine-cytidine kinase (UCK) 2 is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Recent studies have shown that UCK2 is overexpressed in many types of cancer and may play a crucial role in activating antitumor prodrugs in human cancer cells. In the current study, we evaluated the potential prognostic value of UCK2 in breast cancer. Methods: We searched public databases to explore associations between UCK2 gene expression and clinical parameters in patients with breast cancer. Gene set enrichment analysis (GSEA) was performed to identify biological pathways associated with UCK2 gene expression levels. Survival analyses were performed using 10 independent large-scale breast cancer microarray datasets. Results: We found that UCK2 mRNA expression was elevated in breast cancer tissue compared with adjacent nontumorous tissue or breast tissue from healthy controls. High UCK2 levels were correlated with estrogen receptor negativity (p<0.001), advanced tumor grade (p<0.001), and poor tumor differentiation (p<0.001). GSEA revealed that UCK2-high breast cancers were enriched for gene sets associated with metastasis, progenitor-like phenotypes, and poor prognosis. Multivariable Cox proportional hazards regression analyses of microarray datasets verified that high UCK2 gene expression was associated with poor overall survival in a dose-response manner. The prognostic power of UCK2 was superior to that of TNM staging and comparable to that of multiple gene signatures. Conclusion: These findings suggest that UCK2 may be a promising prognostic biomarker for patients with breast cancer. |
| 学科主题 | Oncology |
| WOS关键词 | GENE-EXPRESSION SIGNATURE ; CLASSIFICATION ; SURVIVAL ; PATHWAY ; CELLS |
| 语种 | 英语 |
| WOS记录号 | WOS:000404833800002 |
| 出版者 | KOREAN BREAST CANCER SOC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1063]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Taipei Med Univ, Div Gen Med, Coll Med, Taipei, Taiwan; 2.Taipei Med Univ, Ctr Translat Med, Integrated Lab, Taipei, Taiwan, 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China; 4.Huzhou Women & Children Hosp, Prenatal Diagnost Ctr, Huzhou, Peoples R China; 5.Zhejiang Chinese Med Univ, Sch Basic Med Sci, Dept Epidemiol & Biostat, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China; 6.Hangzhou Hope Biotechnol Co, Hangzhou, Zhejiang, Peoples R China; 7.Sino Amer Canc Fdn, Calif Canc Inst, Biomarkers Dev, Temple, TX USA; |
| 推荐引用方式 GB/T 7714 | Shen, Guosong,He, Pingya,Mao, Yingying,et al. Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis[J]. JOURNAL OF BREAST CANCER,2017,20(2):132-141. |
| APA | Shen, Guosong.,He, Pingya.,Mao, Yingying.,Li, Peipei.,Luh, Frank.,...&,.(2017).Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis.JOURNAL OF BREAST CANCER,20(2),132-141. |
| MLA | Shen, Guosong,et al."Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis".JOURNAL OF BREAST CANCER 20.2(2017):132-141. |
入库方式： OAI收割
来源：上海营养与健康研究所
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