Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer
文献类型：期刊论文
| 作者 | Zhan, Xiaohui2,3; Li, Yixue2,3; Dong, Chuanpeng1; Liu, Gang1; Liu, Lei1; Li, Yixue4; , |
| 刊名 | ONCOTARGETS AND THERAPY
 |
| 出版日期 | 2017 |
| 卷号 | 10期号:-页码:2805-2813 |
| 关键词 | lncRNA ovarian cancer prognostic gene signature survival |
| ISSN号 | 1178-6930 |
| DOI | 10.2147/OTT.S128797 |
| 文献子类 | Article |
| 英文摘要 | Ovarian cancer is one of the most common and lethal gynecological malignancies. The diagnosis of ovarian cancer is often at an advanced stage. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) play important roles during ovarian tumorigenesis. In this study, using the lncRNA-mining approach, we analyzed lncRNA expression profiles of 493 ovarian cancer patients from Gene Expression Omnibus datasets, and identified a signature group of seven lncRNAs (BC037530, AK021924, AK094536, AK094536, BC062365, BC004123 and BC007937) associated with patient survival in the training dataset GSE9891. We also formulated a risk score model to divide patients into low-risk and high-risk groups based on the expression of these seven lncRNAs. We further validated the predictive power of our risk score model in two other datasets, GSE26193 and GSE63885. Our analysis showed that the seven-lncRNA signature can serve as an independent predictor apart from Federation of Gynecology and Obstetrics (FIGO) stage and patient age. Further investigation revealed the seven-lncRNA signature correlated with few critical signaling pathways involved in cancer. Combined, all these findings strongly support that the seven-lncRNA signature can serve as a strong prognosis biomarker. |
| 学科主题 | Biotechnology & Applied Microbiology ; Oncology |
| WOS关键词 | EXPRESSION ; PREDICTION ; PATHWAYS ; LYMPHOMA ; PROMOTES ; SURVIVAL ; SCORE |
| 语种 | 英语 |
| WOS记录号 | WOS:000402657600002 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1064]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, 131 Dong Rd, Shanghai 200032, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Yueyang Rd, Shanghai 200031, Peoples R China; 3.Univ Chinese Acad Sci, Beijing, Peoples R China; 4.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhan, Xiaohui,Li, Yixue,Dong, Chuanpeng,et al. Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer[J]. ONCOTARGETS AND THERAPY,2017,10(-):2805-2813. |
| APA | Zhan, Xiaohui.,Li, Yixue.,Dong, Chuanpeng.,Liu, Gang.,Liu, Lei.,...&,.(2017).Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer.ONCOTARGETS AND THERAPY,10(-),2805-2813. |
| MLA | Zhan, Xiaohui,et al."Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer".ONCOTARGETS AND THERAPY 10.-(2017):2805-2813. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。