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Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification

文献类型：期刊论文

作者Ge, Qian2,3,4; Ruan, Cheng-Chao2,3,4; Ma, Yu2,3,4; Tang, Xiao-Feng2,3,4; Wu, Qi-Hong2,3,4; Wang, Ji-Guang2,3,4; Zhu, Ding-Liang2,3,4; Gao, Ping-Jin1,2,3,4,5; Ruan, Cheng-Chao1,5; ,
刊名SCIENTIFIC REPORTS
出版日期2017
卷号7期号:-页码:40253
关键词obesity disease gene OMIM disease class protein-protein interaction
ISSN号2045-2322
DOI10.1038/srep40253
文献子类Article
英文摘要Vascular calcification (VC) is a highly regulated ectopic mineral deposition process involving immune cell infiltration in the vasculatures, which has been recognized to be promoted by hypertension. The matricellular glycoprotein osteopontin (OPN) is strongly induced in myeloid cells as a potential inflammatory mediator of vascular injury. This study aims to examine whether OPN is involved in the regulation of macrophage activation and osteoclast formation in hypertensive subjects with VC. We firstly found an increased proportion of CD11c+CD163-pro-inflammatory peripheral monocytes in hypertensive subjects with VC compared to those without VC by flow cytometric analysis. Primary cultured macrophages from hypertensive subjects with VC also showed altered expression profile of inflammatory factors and higher serum OPN level. Exogenous OPN promoted the differentiation of peripheral monocytes into an alternative, anti-inflammatory phenotype, and inhibited macrophage-to-osteoclast differentiation from these VC patients. In addition, calcified vessels showed increased osteoclasts accumulation accompanied with decreased macrophages infiltration in the of hypertensive subjects. Taken together, these demonstrated that OPN exerts an important role in the monocytes/macrophage phenotypic differentiation from hypertensive patients with VC, which includes reducing inflammatory factor expression and attenuating osteoclast formation.
学科主题Science & Technology - Other Topics
WOS关键词CORONARY-ARTERY-DISEASE ; CHRONIC KIDNEY-DISEASE ; IN-VITRO ; SERUM OSTEOPROTEGERIN ; CHRONIC INFLAMMATION ; DENDRITIC CELLS ; VICIOUS CYCLE ; ATHEROSCLEROSIS ; POLARIZATION ; EXPRESSION
语种英语
WOS记录号WOS:000392097900001
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/1065]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Vasc Biol, Shanghai, Peoples R China;
2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, State Key Lab Med Gen,Shanghai Key Lab Hypertens, Shanghai, Peoples R China;
3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Hypertens, Shanghai, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens, Shanghai, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Ge, Qian,Ruan, Cheng-Chao,Ma, Yu,et al. Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification[J]. SCIENTIFIC REPORTS,2017,7(-):40253.
APA Ge, Qian.,Ruan, Cheng-Chao.,Ma, Yu.,Tang, Xiao-Feng.,Wu, Qi-Hong.,...&,.(2017).Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification.SCIENTIFIC REPORTS,7(-),40253.
MLA Ge, Qian,et al."Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification".SCIENTIFIC REPORTS 7.-(2017):40253.

入库方式： OAI收割

来源：上海营养与健康研究所

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