No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population
文献类型：期刊论文
| 作者 | Bi, Yan1,2; Huang, Xiaoye1,2; Niu, Weibo1,2; Chen, Shiqing1,2; Wu, Xi1,2; Cao, Yanfei1,2; Zhan, Rui1,2; Yang, Fengping1,2; Wang, Lu1,2; Li, Weidong1,2 |
| 刊名 | PSYCHIATRY RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 253期号:-页码:398-400 |
| 关键词 | SNP Schizophrenia Association |
| ISSN号 | 0165-1781 |
| DOI | 10.1016/j.psychres.2017.02.051 |
| 文献子类 | Article |
| 英文摘要 | This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results. In summary, our study denies the major role of these SNPs within the three genes for schizophrenia in Han Chinese. |
| 学科主题 | Psychiatry |
| WOS关键词 | RECEPTOR GENE ; CANDIDATE GENES ; SEROTONIN ; DOPAMINE ; SUSCEPTIBILITY |
| 语种 | 英语 |
| WOS记录号 | WOS:000403739100058 |
| 出版者 | ELSEVIER IRELAND LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1067]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Inst Mental Hlth, 600 South Wan Ping Rd, Shanghai 200030, Peoples R China, 2.Shanghai Jiao Tong Univ, Biox Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, 1954 Huashan Rd, Shanghai 200030, Peoples R China; 3.Fudan Univ, Inst Biomed Sci, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Bi, Yan,Huang, Xiaoye,Niu, Weibo,et al. No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population[J]. PSYCHIATRY RESEARCH,2017,253(-):398-400. |
| APA | Bi, Yan.,Huang, Xiaoye.,Niu, Weibo.,Chen, Shiqing.,Wu, Xi.,...&,.(2017).No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population.PSYCHIATRY RESEARCH,253(-),398-400. |
| MLA | Bi, Yan,et al."No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population".PSYCHIATRY RESEARCH 253.-(2017):398-400. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。