Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium
文献类型：期刊论文
| 作者 | Zhou, Ying2,3; Qiu, Hongxiang2; Xu, Shuhua2,3; Qiu, Hongxiang4; Xu, Shuhua1,5; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:1-10 |
| 关键词 | myocardial infarction ischemia reperfusion late reperfusion immune response inflammatory cytokines angiogenesis cyclosporine A |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep43054 |
| 文献子类 | Article |
| 英文摘要 | Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | POPULATIONS ; ANCESTRY ; DYNAMICS ; DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000394746800001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1068]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 2.Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Max Planck Independent Res Grp Populat Genom,Shan, Shanghai 200031, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Univ Hong Kong, Dept Math, Shatin, Hong Kong, Peoples R China; 5.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhou, Ying,Qiu, Hongxiang,Xu, Shuhua,et al. Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium[J]. SCIENTIFIC REPORTS,2017,7(-):1-10. |
| APA | Zhou, Ying,Qiu, Hongxiang,Xu, Shuhua,Qiu, Hongxiang,Xu, Shuhua,&,.(2017).Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium.SCIENTIFIC REPORTS,7(-),1-10. |
| MLA | Zhou, Ying,et al."Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium".SCIENTIFIC REPORTS 7.-(2017):1-10. |
入库方式： OAI收割
来源：上海营养与健康研究所
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