Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
文献类型：期刊论文
| 作者 | Suo, Caixia1,3; Fan, Zhiqin1,3; Qiu, Ju1,3; Zhou, Liang2; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:5166 |
| 关键词 | paralytic shellfish poisoning (PSP) toxins LC-MS/MS dispersive solid-phase extraction (dSPE) saxitoxin |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-04091-z |
| 文献子类 | Article |
| 英文摘要 | Perfluorooctane sulfonate (PFOS) is an environmental contaminant that has been manufactured to be used as surfactants and repellents in industry. Due to long half-life for clearance and degradation, PFOS is accumulative in human body and has potential threat to human health. Previous studies have shown the development and function of immune cells can be affected by PFOS. Although PFOS has a high chance of being absorbed through the oral route, whether and how PFOS affects immune cells in the gut is unknown. Using mouse model of Citrobacter rodentium infection, we investigated the role of PFOS on intestinal immunity. We found at early phase of the infection, PFOS inhibited the expansion of the pathogen by promoting IL-22 production from the group 3 innate lymphoid cell (ILC3) in an aryl hydrocarbon receptor dependent manner. Nevertheless, persistent PFOS treatment in mice finally led to a failure to clear the pathogen completely. At late phase of infection, enhanced bacterial counts in PFOS treated mice were accompanied by increased inflammatory cytokines, reduced mucin production and dysbiosis, featured by decreased level of Lactobacillus casei, Lactobacillus johnsonii and increased E. coli. Our study reveals a deleterious consequence in intestinal bacterial infection caused by PFOS accumulation. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; CITROBACTER-RODENTIUM INFECTION ; INNATE LYMPHOID-CELLS ; ROR-GAMMA-T ; PROBIOTIC LACTOBACILLUS-REUTERI ; SHORT-TERM EXPOSURE ; INDUCED COLITIS ; PERFLUORINATED COMPOUNDS ; ENHANCED SEVERITY ; HOST-DEFENSE |
| 语种 | 英语 |
| WOS记录号 | WOS:000405421400006 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1070]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China; 2.Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, Gainesville, FL 32608 USA, 3.Shanghai Jiao Tong Univ, Sch Med, Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Suo, Caixia,Fan, Zhiqin,Qiu, Ju,et al. Perfluorooctane sulfonate affects intestinal immunity against bacterial infection[J]. SCIENTIFIC REPORTS,2017,7(-):5166. |
| APA | Suo, Caixia,Fan, Zhiqin,Qiu, Ju,Zhou, Liang,&,.(2017).Perfluorooctane sulfonate affects intestinal immunity against bacterial infection.SCIENTIFIC REPORTS,7(-),5166. |
| MLA | Suo, Caixia,et al."Perfluorooctane sulfonate affects intestinal immunity against bacterial infection".SCIENTIFIC REPORTS 7.-(2017):5166. |
入库方式： OAI收割
来源：上海营养与健康研究所
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