PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs
文献类型：期刊论文
| 作者 | Zhu, Zhexin6,7; Li, Chunliang7; Ding, Jianyi6,7; Huang, Xin6,7; Zhou, Chenlin7; Jin, Ying1,7; Zeng, Yanwu1; Qu, Zepeng1; Gu, Junjie1; Ge, Laixiang1 |
| 刊名 | CELL STEM CELL
 |
| 出版日期 | 2017 |
| 卷号 | 20期号:2页码:274-+ |
| 关键词 | Gastric cancer Differential coexpression analysis Differential regulation analysis Combinatorial gene regulatory network |
| ISSN号 | 1934-5909 |
| DOI | 10.1016/j.stem.2016.11.002 |
| 文献子类 | Article |
| 英文摘要 | The chromatin landscape and cellular metabolism both contribute to cell fate determination, but their interplay remains poorly understood. Using genome-wide siRNA screening, we have identified prohibitin (PHB) as an essential factor in self-renewal of human embryonic stem cells (hESCs). Mechanistically, PHB forms protein complexes with HIRA, a histone H3.3 chaperone, and stabilizes the protein levels of HIRA complex components. Like PHB, HIRA is required for hESC self-renewal. PHB and HIRA act together to control global deposition of histone H3.3 and gene expression in hESCs. Of particular note, PHB and HIRA regulate the chromatin architecture at the promoters of isocitrate dehydrogenase genes to promote transcription and, thus, production of a-ketoglutarate, a key metabolite in the regulation of ESC fate. Our study shows that PHB has an unexpected nuclear role in hESCs that is required for self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization to a metabolic circuit. |
| 学科主题 | Cell Biology |
| WOS关键词 | EMBRYONIC STEM-CELLS ; HISTONE VARIANT H3.3 ; SELF-RENEWAL ; CRISTAE MORPHOGENESIS ; ACTIVE CHROMATIN ; PROHIBITIN ; PLURIPOTENCY ; DIFFERENTIATION ; LINES ; PROLIFERATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000396374700014 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/1073]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Mol Dev Biol, 225 South Chongqing Rd, Shanghai 200025, Peoples R China; 2.Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA; 3.Albert Einstein Coll Med, Dept Genet, Bronx, NY 10461 USA; 4.Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA; 5.St Jude Childrens Res Hosp, Dept Tumor Cell Biol, 332 N Lauderdale St, Memphis, TN 38105 USA, 6.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 7.Shanghai Jiao Tong Univ, Key Lab Stem Cell Biol, CAS Ctr Excellence Mol Cell Sci,Chinese Acad Sci, Inst Hlth Sci,Shanghai Inst Biol Sci,Sch Med, 320 Yueyang Rd, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Zhexin,Li, Chunliang,Ding, Jianyi,et al. PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs[J]. CELL STEM CELL,2017,20(2):274-+. |
| APA | Zhu, Zhexin.,Li, Chunliang.,Ding, Jianyi.,Huang, Xin.,Zhou, Chenlin.,...&,.(2017).PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs.CELL STEM CELL,20(2),274-+. |
| MLA | Zhu, Zhexin,et al."PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs".CELL STEM CELL 20.2(2017):274-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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